Morphine‐Induced Changes in Histamine Dynamics in Mouse Brain
Morphine‐Induced Changes in Histamine Dynamics in Mouse Brain
复制标题
吗啡引起的小鼠大脑组胺动力学变化
DOI：
10.1111/j.1471-4159.1985.tb04051.x
复制
发表时间：
1985
影响因子：
4.7
通讯作者：
K. Saeki
中科院分区：
文献类型：
--
作者：
M. Nishibori;R. Oishi;Y. Itoh;K. Saeki
摘要：观察了急性吗啡处理对小鼠脑和脊髓组胺(HA)池的影响。吗啡(1-50 mg/kg，S.C.)单独给药对大脑中HA及其主要代谢物端甲基组胺(t-MH)的稳定水平没有显著影响。然而，依赖于所测试的剂量，吗啡显著增加帕吉林(65 mg/kg，i.p)诱导的t-MH的蓄积，这种作用可被纳洛酮拮抗。组氨酸脱羧酶的特异性抑制剂α-氟甲基组氨酸(α-FMH)(50 mg/kg，ip)可降低脑内HA水平，原因是HA池几乎完全耗尽，周转迅速。吗啡进一步降低α-FMH处理小鼠的脑透明质酸水平。单独使用吗啡显著降低了脊髓中HA的水平，而脊髓是HA周转非常缓慢的区域。这些结果表明，急性吗啡处理通过阿片受体增加神经元HA的周转，并且这种阿片剂也从缓慢的翻转池中释放HA(S)。
Abstract: The effect of the acute morphine treatment on histamine (HA) pools in the brain and the spinal cord was examined in mice. Morphine (1–50 mg/kg, s.c.) administered alone caused no significant change in the steadystate levels of HA and its major metabolite, tele‐methylhistamine (t‐MH), in the brain. However, depending on the doses tested, morphine significantly enhanced the pargyline (65 mg/kg, i.p.)‐induced accumulation of t‐MH and this effect was antagonized by naloxone. A specific inhibitor of histidine decarboxylase, α‐fluoromethylhistidine (α‐FMH) (50 mg/kg, i.p.), decreased the brain HA level in consequence of the almost complete depletion of the HA pool with a rapid turnover. Morphine further decreased the brain HA level in α‐FMH‐pretreated mice. Morphine administered alone significantly reduced the HA level in the spinal cord, an area where the turnover of HA is very slow. These results suggest that the acute morphine treatment increases the turnover of neuronal HA via opioid receptors, and this opiate also releases HA from a slowly turning over pool(s).