The effects of lesions of the entorhinal cortex and the horizontal nucleus of the diagonal band of broca upon performance of a spatial location recognition task.
The effects of lesions of the entorhinal cortex and the horizontal nucleus of the diagonal band of broca upon performance of a spatial location recognition task.
复制标题
内嗅皮层和布罗卡对角带水平核的损伤对空间位置识别任务执行的影响。
DOI：
10.1016/0166-4328(94)90002-7
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发表时间：
1994
影响因子：
2.7
通讯作者：
Kesner,RP
中科院分区：
文献类型：
--
作者：
Johnson,DL;Kesner,RP
研究了Broca斜角带水平核（HNDB）和内嗅皮层（ENTO）损伤对空间位置识别任务的影响。两个假设的内嗅皮层功能被认为是在解释的数据。第一种假设认为海马和内嗅皮层之间的解剖学接近和相互连接表明功能相似。第二种假说承认海马体和内嗅皮层的相互联系，但认为这两个结构具有不同的功能。海马主要从内侧隔（MS）接收输入，然而，内嗅皮层接收来自HNDB和MS的输入。该研究试图评估ENTO和HNDB在空间位置识别任务中的功能，目的是将研究结果与海马和MS的先前研究进行比较。HNDB损伤和ENTO损伤的动物的表现对于所有序列均处于偶然水平。岗位结果表明，HNDB与基底前脑其他结构之间存在功能差异。此外，ENTO组的性能缺陷与海马损伤后观察到的性能缺陷没有差异。
The effects of lesions of the horizontal nucleus of the diagonal band of Broca (HNDB) and the entorhinal cortex (ENTO) upon performance of a spatial location recognition task were assessed. Two hypotheses of entorhinal cortex function were considered in interpretation of the data. The first hypothesis assumes that the anatomical proximity and interconnections between the hippocampus and the entorhinal cortex are indicative of a functional similarity. The second hypothesis recognizes the interconnections of the hippocampus and the entorhinal cortex, but posits that the two structures have distinct functions. The hippocampus receives input primarily from the medial septum (MS), whereas the entorhinal cortex receives input from the HNDB and the MS. The study attempted to assess the function of the ENTO and the HNDB in a spatial location recognition task with the intent of comparing the findings to previous research of the hippocampus and MS. Performance of animals with HNDB lesions and the ENTO lesions was at chance levels for all serial positions. Results indicated that there are functional differences between the HNDB and other basal forebrain structures. Further, the performance deficit of the ENTO group does not differ from that observed following lesions of the hippocampus.