GENETICS OF OBESITY IN ADULT ADOPTEES AND THEIR BIOLOGICAL SIBLINGS
GENETICS OF OBESITY IN ADULT ADOPTEES AND THEIR BIOLOGICAL SIBLINGS
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DOI：
10.1136/bmj.298.6666.87
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发表时间：
1989-01-14
影响因子：
105.7
通讯作者：
SCHULSINGER, F
中科院分区：
文献类型：
--
作者：
SORENSEN, TIA;PRICE, RA;SCHULSINGER, F
一项关于遗传对成年期肥胖影响的收养研究进行了，其中将在生命早期与亲生父母分离的被收养者与由亲生父母抚养的生物学上的全同胞和半同胞进行了比较。这些被收养者代表了四个群体，他们从更大的人群中抽样，分为瘦、中等体重、超重或肥胖。体重和身高获得了115个完整的兄弟姐妹57收养和850半兄弟姐妹341收养。在完整的兄弟姐妹的体重指数（公斤/平方米）显着增加的被收养者的体重。同父异母兄弟姐妹的身体质量指数在四个体重组的被收养者中有稳定但较弱的增长。有没有显着的相互作用与性别的被收养者，性别的兄弟姐妹，或（半兄弟姐妹）性别的共同父母。与同父异母的兄弟姐妹和（以前的）亲生父母的研究结果相反，超重和肥胖的被收养者的同胞兄弟姐妹之间的体重指数有显著的增加。生活在同一环境中的成年人的肥胖程度似乎受到独立于性别的遗传因素的影响，其中可能包括多基因以及主要基因对肥胖的影响。
An adoption study of genetic effects on obesity in adulthood was carried out in which adoptees separated from their natural parents very early in life were compared with their biological full and half siblings reared by their natural parents. The adoptees represented four groups who by sampling from a larger populations were categorised as either thin, medium weight, overweight, or obese. Weight and height were obtained for 115 full siblings of 57 adoptees and for 850 half siblings of 341 adoptees. In full siblings body mass index (kg/m2) significantly increased with weight of the adoptees. Body mass index of the half siblings a steady but weaker increase across the four weight groups of adoptees. There were no significant interactions with sex of the adoptees, sex of the siblings, or (for the half siblings) sex of the common parent. In contrast with the findings in half siblings and (previously) the natural parents there was a striking, significant increase in body mass index between full siblings of overweight and obese adoptees. The degree of fatness in adults living in the same environment appears to be influenced by genetic factors independent of sex, which may include polygenic as well as major gene effects on obesity.