Plant derived cyclic peptides.
Plant derived cyclic peptides.
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DOI：
10.1042/bst20200881
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发表时间：
2021-06-30
影响因子：
3.9
通讯作者：
Wilson DT
中科院分区：
文献类型：
--
作者：
Daly NL;Wilson DT
环肽广泛分布于植物界，具有不同的序列、结构和生物活性。这些肽及其不寻常的生物合成所带来的潜在应用已经吸引了研究人员多年的注意力。在过去的二十年中，已经发现了几种植物环肽的基因序列，但直到最近，我们才开始了解与其生物合成相关的复杂性。最近的研究集中在三个主要类别的植物源性环肽，即orbitides，SFTI相关肽和环肽。在这个小型审查中，我们讨论了这些家庭的已知序列和结构多样性的扩展，深入了解参与生物合成的酶，令人兴奋的应用，其中包括目前在临床试验中用于治疗多发性硬化症的环肽，以及正在开发的新的生产方法，以实现植物环肽作为药物或农业制剂的潜力。
Cyclic peptides are widespread throughout the plant kingdom, and display diverse sequences, structures and bioactivities. The potential applications attributed to these peptides and their unusual biosynthesis has captivated the attention of researchers for many years. Several gene sequences for plant cyclic peptides have been discovered over the last two decades but it is only recently that we are beginning to understand the intricacies associated with their biosynthesis. Recent studies have focussed on three main classes of plant derived cyclic peptides, namely orbitides, SFTI related peptides and cyclotides. In this mini-review, we discuss the expansion of the known sequence and structural diversity in these families, insights into the enzymes involved in the biosynthesis, the exciting applications which includes a cyclotide currently in clinical trials for the treatment of multiple sclerosis, and new production methods that are being developed to realise the potential of plant cyclic peptides as pharmaceutical or agricultural agents.