OXYGEN-CONSUMPTION OF THE LIVING HUMAN BRAIN MEASURED AFTER A SINGLE INHALATION OF POSITRON EMITTING OXYGEN
OXYGEN-CONSUMPTION OF THE LIVING HUMAN BRAIN MEASURED AFTER A SINGLE INHALATION OF POSITRON EMITTING OXYGEN
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DOI：
10.1038/jcbfm.1992.28
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发表时间：
1992-03-01
影响因子：
6.3
通讯作者：
GJEDDE, A
中科院分区：
文献类型：
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作者：
OHTA, S;MEYER, E;GJEDDE, A
我们测量了团注[O-15]O2后标记氧在脑内累积产生的O-15标记水的冲洗率，并与H-2O-15测量的标记水的冲洗率进行了比较。与最初的预期相反，标记氧产生的放射性水未能以外源水预测的速度离开脑组织。因此，使用单独测量的外源水清除值导致了耗氧量的计算错误。本文提出了一种新的方法，通过在单次氧气研究中产生耗氧量来消除误差。我们使用时间加权积分来估计三个参数，包括从血液到脑的单向清除(K1O2)、脑内分布体积的分数清除(K2O2)和血管体积校正(V(O))。我们证明，通过这种新方法可以以可接受的精度估计从血液到大脑的氧气清除，并且新方法产生了一种可靠的氧气消耗测量方法。
We measured the rate of washout of O-15-labeled water generated from labeled oxygen accumulated in brain after bolus [O-15]O2 inhalation, and compared the washout with that of labeled water measured with H-2 O-15. Contrary to the original expectation, the radioactive water generated from labeled oxygen failed to leave the brain tissue at the rate predicted by exogenous water. Therefore, the use of a separately measured value for exogenous water clearance led to an error in the calculation of oxygen consumption. A new method presented in this paper eliminated the error by yielding oxygen consumption in a single oxygen study. We used time-weighted integration to estimate three parameters, including the unidirectional clearance from blood to brain (K1O2), the fractional clearance of the distribution volume in brain (k2O2), and the vascular volume correction (V(o)). We showed that the clearance of oxygen from blood to brain can be estimated with acceptable precision by this new approach, and that the new method yields a reliable measure of oxygen consumption.