3D virtual human atria: A computational platform for studying clinical atrial fibrillation.
3D virtual human atria: A computational platform for studying clinical atrial fibrillation.
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DOI：
10.1016/j.pbiomolbio.2011.06.011
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发表时间：
2011-10
影响因子：
3.8
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Aslanidi OV;Colman MA;Stott J;Dobrzynski H;Boyett MR;Holden AV;Zhang H
尽管有大量的实验和临床数据的基础上的离子，细胞和组织基板，常见的房性心律失常（如心房颤动，AF）的机制所产生的功能相互作用在整个心房水平仍然不清楚。计算建模提供了一个定量框架，用于整合这种多尺度数据，并了解心脏所有部位的集体时空动态中出现的致心律失常行为。在这项研究中，我们已经开发了一个多尺度层次的生物病理学详细的计算模型的人类心房-三维虚拟人类心房。首先，将人窦房结（SAN）和周围心房肌中组织几何形状和纤维取向的扩散张量MRI重建集成到从Visible Human数据集解剖的整个心房的3D模型中。将解剖模型与异质心房动作电位（AP）模型相结合，并用于模拟各种条件下人体心房中的AP传导：正常节律下的SAN起搏和心房激动，快速心房起搏期间规则AP波前的分解，以及多重再-进入小波特征的AF。贡献的组织的不同属性的机制的正常节奏和AF embrymogenesis进行了研究和讨论。将心房本身的3D模型合并到躯干模型中，以模拟正常和运动条件下的体表ECG模式。因此，一个国家的最先进的计算平台已经开发，它可以用于研究心房传导和心房肌生成过程中的多尺度电现象。这种模拟的结果可以直接与实验的电生理和内分泌映射数据，以及临床心电图记录进行比较。更重要的是，虚拟人心房可以提供用于从体内整个心脏直接解剖心房壁内的3D兴奋传播过程的经验证的手段，这超出了实验或临床设置的当前技术能力。
Despite a vast amount of experimental and clinical data on the underlying ionic, cellular and tissue substrates, the mechanisms of common atrial arrhythmias (such as atrial fibrillation, AF) arising from the functional interactions at the whole atria level remain unclear. Computational modelling provides a quantitative framework for integrating such multi-scale data and understanding the arrhythmogenic behaviour that emerges from the collective spatio-temporal dynamics in all parts of the heart. In this study, we have developed a multi-scale hierarchy of biophysically detailed computational models for the human atria – 3D virtual human atria. Primarily, diffusion tensor MRI reconstruction of the tissue geometry and fibre orientation in the human sinoatrial node (SAN) and surrounding atrial muscle was integrated into the 3D model of the whole atria dissected from the Visible Human dataset. The anatomical models were combined with the heterogeneous atrial action potential (AP) models, and used to simulate the AP conduction in the human atria under various conditions: SAN pacemaking and atrial activation in the normal rhythm, break-down of regular AP wave-fronts during rapid atrial pacing, and the genesis of multiple re-entrant wavelets characteristic of AF. Contributions of different properties of the tissue to the mechanisms of the normal rhythm and AF arrhythmogenesis are investigated and discussed. The 3D model of the atria itself was incorporated into the torso model to simulate the body surface ECG patterns in the normal and arrhythmic conditions. Therefore, a state-of-the-art computational platform has been developed, which can be used for studying multi-scale electrical phenomena during atrial conduction and arrhythmogenesis. Results of such simulations can be directly compared with experimental electrophysiological and endocardial mapping data, as well as clinical ECG recordings. More importantly, the virtual human atria can provide validated means for directly dissecting 3D excitation propagation processes within the atrial walls from an in vivo whole heart, which are beyond the current technical capabilities of experimental or clinical set-ups.
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