First clinical experiences with a novel 3D-collagen gel (CaReS®) for the treatment of focal cartilage defects in the knee
First clinical experiences with a novel 3D-collagen gel (CaReS®) for the treatment of focal cartilage defects in the knee
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DOI：
10.1055/s-2006-933445
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发表时间：
2006-05-01
期刊：
影响因子：
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通讯作者：
Schneider, U.
中科院分区：
文献类型：
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作者：
Andereya, S.;Maus, U.;Schneider, U.
目的：在这项前瞻性研究中，我们提出了一种基于基质的软骨细胞移植新技术，用于治疗局灶性软骨缺损。方法：采用植入自体软骨细胞 (CaReS (R)) 的 3D-I 型胶原凝胶治疗 22 例股骨软骨或骨软骨缺损患者。描述了这种新方法的总体处理，并给出了 ICRS 评分的 2 年后随访结果。结果：14例患者因局灶性软骨病变而接受治疗，其中8例需重建软骨下骨。平均缺陷尺寸为 6 cm(2)。在所有情况下，细胞接种的基质样品都可以用纤维蛋白胶固定，没有任何问题。平均手术时间69分钟，手术入路长度8.2厘米。无需观察手术特有的问题。经过 3 个月或 6 个月直至 2 年的随访后，发现 IKDC 评分、功能评分和总体评分显着改善。术后 2 年后，对 13 名患者进行了评估，84.6% 的患者将 CaReS (R) 基于基质的缺损治疗评为良好至优秀。结论：使用细胞接种的 3D 胶原凝胶治疗缺损很容易处理，并且在 2 年后随访后具有良好的临床结果。需要对更多患者数量、更长随访时间以及组织学和生物力学样本分析进行进一步研究，以便将该方法确立为传统 ACT 的改进。
Aim: In this prospective study we present a novel technique of matrix-based chondrocyte transplantation for the treatment of focal cartilage defects. Method: 22 patients with chondral or osteochondral femoral defects were treated with 3D-collagen type-I gel seeded with autologous chondrocytes (CaReS (R)). Overall handling of this novel method is described, and results after 2 years follow-up with regard to the ICRS-score are presented. Results: 14 patients were treated because of a focal chondral lesion, in 8 cases subchondral bone had to be reestablished. The average defect size was 6 cm(2). In all cases cell-seeded matrix samples could be fixed with fibrin glue without any problems. The average surgery time was 69 min, length of the surgical approach was 8.2 cm. No surgery-specific problems had to be observed. A significant improvement in IKDC-score, functional score and overall rating after 3 or 6 months up to 2 years follow-up was detected. After 2 years post-OP 13 Patients were evaluated and matrix-based defect treatment by CaReS (R) was rated good to excellent by 84.6% of the patients. Conclusion: Defect treatment with cell-seeded 3D-collagen gel is easy to handle with a good clinical outcome after 2 years follow-up. Further investigations with higher patient number, longer follow-up time and histological and biomechanical sample analysis are needed in order to establish this method as an improvement of conventional ACT.