An overview of post exposure prophylaxis for HIV in health care personals: Gujarat scenario.
An overview of post exposure prophylaxis for HIV in health care personals: Gujarat scenario.
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医护人员艾滋病毒暴露后预防概述：古吉拉特邦情景。
DOI：
10.4103/0253-7184.81247
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发表时间：
2011-01
影响因子：
0.4
通讯作者：
Shah A
中科院分区：
文献类型：
--
作者：
Shevkani M;Kavina B;Kumar P;Purohit H;Nihalani U;Shah A
经皮接触受艾滋病毒感染的血液后感染艾滋病毒的平均风险为0.3%。艾滋病毒暴露后预防（PEP）是指一套全面的服务，以预防暴露个体感染艾滋病毒，其中暴露可以是职业性/非职业性的，并根据风险评估提供短期（28天）抗逆转录病毒药物。它还包括咨询和在取得受影响者和来源的知情同意后进行相关的实验室调查。PEP抑制病毒初始接种物的复制，从而防止慢性HIV感染的建立，并且在2小时内开始时最有效，但肯定在72小时内。本来文涉及古吉拉特邦278例PEP病例的登记，涉及各种决定因素、其状况和艾滋病毒血清阳性结果。
Average risk of acquiring HIV infection after a percutaneous exposure to HIV infected blood is 0.3%. Post exposure prophylaxis (PEP) for HIV refers to a set of comprehensive services to prevent HIV infection in exposed individuals where the exposure can be occupational/ non occupational and a provision of short term (28 days) antiretroviral drugs are given depending on the risk assessment. It also includes counselling and relevant laboratory investigations after taking informed consent of the exposed person and source. PEP inhibits the replication of the initial inoculum of virus and thereby prevents establishment of chronic HIV infection, and is best effective when initiated within 2 hours but certainly within 72 hours. Present communication deals with the registry of 278 cases of PEP from Gujarat in terms of various determinants, their status and the outcome in terms of HIV sero positivity.