Metabolomics: Definitions and Significance in Systems Biology.
Metabolomics: Definitions and Significance in Systems Biology.
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DOI：
10.1007/978-3-319-47656-8_1
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Sussulini, Alessandra
中科院分区：
文献类型：
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作者：
Klassen, Aline;Faccio, Andrea Tedesco;Sussulini, Alessandra
如今，人们越来越有兴趣深入了解生物机制，不仅在分子水平上（生物成分），而且在整个生物体中正在进行的生物过程的影响（生物功能），如系统生物学概念所建立的那样。在此背景下，代谢组学是最强大的生物分析策略之一，它可以获得生物体在生物过程中代谢产物的图片，被认为是一种表型分析工具。简而言之，代谢组学方法在于鉴定和测定正常条件下生物样品（组织、细胞、流体或生物体）中的代谢物（或特定代谢物）的集合，并与疾病、药物治疗、饮食干预或环境调节促进的改变状态进行比较。本章的目的是回顾代谢组学领域的基本原理和定义，并强调其在系统生物学和临床研究中的重要性。
Nowadays, there is a growing interest in deeply understanding biological mechanisms not only at the molecular level (biological components) but also the effects of an ongoing biological process in the organism as a whole (biological functionality), as established by the concept of systems biology. Within this context, metabolomics is one of the most powerful bioanalytical strategies that allow obtaining a picture of the metabolites of an organism in the course of a biological process, being considered as a phenotyping tool. Briefly, metabolomics approach consists in identifying and determining the set of metabolites (or specific metabolites) in biological samples (tissues, cells, fluids, or organisms) under normal conditions in comparison with altered states promoted by disease, drug treatment, dietary intervention, or environmental modulation. The aim of this chapter is to review the fundamentals and definitions used in the metabolomics field, as well as to emphasize its importance in systems biology and clinical studies.