Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs.
Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs.
复制标题
清醒犬对进行性高碳酸血症导致呼吸性窦性心律失常加剧。
DOI：
10.1152/ajpheart.2001.280.5.h2336
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
J. Hayano
中科院分区：
文献类型：
--
作者：
F. Yasuma;J. Hayano
呼吸性窦性心律不齐（RSA）可通过在每个呼吸周期内使肺血流量与肺容量相匹配来增强肺气体交换效率。我们检验了RSA作为对高碳酸血症的主动生理反应而增强的假设。我们在清醒的狗进行性高碳酸血症期间测量心电图和动脉血压，这些狗准备了永久性气管造口术和植入的血压遥测装置。RSA的强度采用复解调法作为心率呼吸波动的幅度来连续评估。在3只狗的39次高碳酸血症中，当每分钟通气量达到10和15 l/min时，RSA分别增加了对照水平的38%和43%（两者均P < 0.0001），心率和平均动脉压无显著变化。调整潮气量增加、呼吸频率增加和动脉血压的呼吸波动后，RSA仍显著增加（P < 0.001）。这些观察结果表明，高碳酸血症期间RSA增加不是自主神经平衡或呼吸模式改变的结果，并支持RSA作为高碳酸血症的主动生理反应而增强的假设。
Respiratory sinus arrhythmia (RSA) may serve to enhance pulmonary gas exchange efficiency by matching pulmonary blood flow with lung volume within each respiratory cycle. We examined the hypothesis that RSA is augmented as an active physiological response to hypercapnia. We measured electrocardiograms and arterial blood pressure during progressive hypercapnia in conscious dogs that were prepared with a permanent tracheostomy and an implanted blood pressure telemetry unit. The intensity of RSA was assessed continuously as the amplitude of respiratory fluctuation of heart rate using complex demodulation. In a total of 39 runs of hypercapnia in 3 dogs, RSA increased by 38 and 43% of the control level when minute ventilation reached 10 and 15 l/min, respectively (P < 0.0001 for both), and heart rate and mean arterial pressure showed no significant change. The increases in RSA were significant even after adjustment for the effects of increased tidal volume, respiratory rate, and respiratory fluctuation of arterial blood pressure (P < 0.001). These observations indicate that increased RSA during hypercapnia is not the consequence of altered autonomic balance or respiratory patterns and support the hypothesis that RSA is augmented as an active physiological response to hypercapnia.
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
影响因子：
--
作者：
HIRSCH, JA;BISHOP, B
通讯作者：
BISHOP, B