In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark
In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark
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DOI：
10.3201/eid2503.180297
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发表时间：
2019-03-01
影响因子：
11.8
通讯作者：
Arendrup, Maiken C.
中科院分区：
文献类型：
--
作者：
Hare, Rasmus K.;Gertsen, Jan B.;Arendrup, Maiken C.
我们报告了一个致命的曲霉菌病的情况下，STRAf分型和全基因组测序证实了在体内出现的唑类耐药烟曲霉cyp51A的启动子区的120 bp的串联重复。这一事件，以前仅限于环境，挑战目前的理解唑类耐药的发展，在A。烟熏。
We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.