Cardiovascular control in experimental diabetes
Cardiovascular control in experimental diabetes
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DOI：
10.1590/s0100-879x2002000900010
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发表时间：
2002-09-01
影响因子：
2.3
通讯作者：
Irigoyen, M.C.
中科院分区：
文献类型：
--
作者：
De Angelis, K.;Schaan, B.D.;Irigoyen, M.C.
几项研究报告了糖尿病患者心血管功能和控制的损害。本综述中引用的研究是在链脲佐菌素给药后几天至3个月内进行的，涉及循环的控制。我们观察到，不同外周受体控制血压的早期变化（5天）维持了几个月。此外，压力感受器和化学感受器刺激后观察到的反射反应的损害可能与反射弧（交感神经和副交感神经）的传出支的变化有关，但也不能排除中枢神经系统的变化。肾交感神经活动的变化，在容量扩张过程中被钝化的链脲佐菌素治疗的大鼠，表明适应性利钠利尿反应在糖尿病状态。运动训练对糖尿病心血管功能的改善可能与自主神经系统的改变有关。显然需要补充研究循环控制系统之间的复杂相互作用，以充分解决与糖尿病相关的病理生理变化的管理。
Several studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5 days) in blood pressure control by different peripheral receptors were maintained for several months. Moreover, the impairment of reflex responses observed after baroreceptor and chemoreceptor stimulation was probably related to changes in the efferent limb of the reflex arc (sympathetic and parasympathetic), but changes also in the central nervous system could not be excluded. Changes in renal sympathetic nerve activity during volume expansion were blunted in streptozotocin-treated rats, indicating an adaptive natriuretic and diuretic response in the diabetic state. The improvement of diabetic cardiovascular dysfunction induced by exercise training seems to be related to changes in the autonomic nervous system. Complementary studies about the complex interaction between circulation control systems are clearly needed to adequately address the management of pathophysiological changes associated with diabetes.