Stimulation of prostaglandin biosynthesis by urine of the human fetus may serve as a trigger for parturition.
Stimulation of prostaglandin biosynthesis by urine of the human fetus may serve as a trigger for parturition.
复制标题
人类胎儿尿液刺激前列腺素生物合成可能会触发分娩。
DOI：
10.1126/science.6573023
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Mitchell,MD
中科院分区：
文献类型：
--
作者：
Strickland,DM;Saeed,SA;Casey,ML;Mitchell,MD
Urine of the human fetus stimulated prostaglandin biosynthesis in vitro by increasing the conversion of arachidonic acid into prostaglandins. The stimulatory activity in urine from fetuses delivered at term after labor of spontaneous onset was greater than that in urine from fetuses delivered by cesarean section at term before the onset of labor. Such stimulation of prostaglandin biosynthesis by the fetal membranes, by way of a substance released into the urine and thence into amniotic fluid, could serve as a signal for the initiation of parturition.
