THE PALISADED, ENCAPSULATED NEUROMA (SOLITARY CIRCUMSCRIBED NEUROMA)
THE PALISADED, ENCAPSULATED NEUROMA (SOLITARY CIRCUMSCRIBED NEUROMA)
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DOI：
10.1111/j.1365-2559.1992.tb01010.x
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发表时间：
1992-05-01
期刊：
影响因子：
6.4
通讯作者：
THEAKER, JM
中科院分区：
文献类型：
--
作者：
DAKIN, MC;LEPPARD, B;THEAKER, JM
本文报告41例栅栏状包膜神经瘤的临床及病理特征。它们表现为小的、孤立的、无症状的丘疹，主要发生在中年人的面部。无神经纤维瘤病或多发粘膜神经瘤并存病例。在组织学上，它们具有独特的特征，包括神经束膜衍生的囊内的雪旺细胞和大量轴突的增殖，允许与神经鞘瘤和神经纤维瘤简单可靠的区分。总的来说，栅栏状包裹的神经瘤约占所有真皮神经鞘肿瘤的25%。真正的神经鞘瘤很少发生在真皮。尽管他们原来的名字，许多情况下是不完全封装，我们支持最近的建议，这些病变重新命名为孤立的局限性神经瘤。
We describe the clinical and pathological features of 41 palisaded encapsulated neuromas. They present as small, solitary, asymptomatic papules, predominantly on the face in middle age. No case had co-existent neurofibromatosis or multiple mucosal neuromas. Histologically, they have distinctive features, consisting of a proliferation of Schwann cells and large numbers of axons within a perineurial derived capsule, permitting simple and reliable distinction from schwannomas and neurofibromas. Overall, the palisaded encapsulated neuroma accounts for approximately 25% of all nerve sheath tumours of the dermis. True schwannomas rarely occur in the dermis. Despite their original name, many cases are incompletely encapsulated and we support the recent proposal to rename these lesions solitary circumscribed neuroma.