Mediating Factors Between Parental Socioeconomic Status and Small for Gestational Age in Infants: Results from the Hokkaido Study on Environment and Children’s Health
Mediating Factors Between Parental Socioeconomic Status and Small for Gestational Age in Infants: Results from the Hokkaido Study on Environment and Children’s Health
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父母社会经济地位与婴儿小于胎龄之间的中介因素：北海道环境与儿童健康研究的结果
DOI：
10.1007/s10995-020-03035-w
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发表时间：
2021
影响因子：
2.3
通讯作者：
Kishi Reiko
中科院分区：
文献类型：
--
作者：
Tamura Naomi;Hanaoka Tomoyuki;Ito Kumiko;Araki Atsuko;Miyashita Chihiro;Ito Sachiko;Kobayashi Sumitaka;Ito Yoichi;Minakami Hisanori;Cho Kazutoshi;Endo Toshiaki;Baba Tsuyoshi;Sengoku Kazuo;Miyamoto Toshinobu;Ogasawara Katsuhiko;Kishi Reiko
目的以往的研究表明小于胎龄儿（SGA）与其父母的社会经济地位（SES）之间存在显著的相关性。因此，本研究的目的是检查父母的因素，如母亲吸烟，和孕前体重指数（BMI）可以调解父母SES和SGA.MethodsThe参与者之间的关联本研究的孕妇谁参加了正在进行的出生队列研究，北海道研究，在怀孕的头三个月。共有14，593例活产单胎分娩纳入统计分析，其中1011例（6.9%）为SGA。采用两个结构方程模型来评估父母SES，父母的特点，和SGA之间的关联。ResultsThe低SES对SGA的影响是直接介导的母亲孕前BMI，在第三个三个月期间吸烟，和酒精消费量在第一个模型，这是基于独立的中介因素之间的关联的假设。在第二个模型中，另外考虑了第一个模型的介导因素，怀孕期间吸烟介导了父母SES的下降，从而增加了SGA。此外，怀孕吸烟状况的增加增加，降低孕产妇孕前BMI及其对SGA.Conclusions PracticeIn这项研究中，我们观察到的独立中介作用的孕产妇孕前BMI，吸烟，饮酒量在怀孕期间低SES，因此，SGA，与SES的额外的中介途径吸烟，低BMI的SGA。
ObjectivesPrevious studies indicated a significant association between small for gestational age (SGA) in infants and their parents' socioeconomic status (SES). Thus, this study aimed to examine if parental factors, such as maternal smoking, and the pre-pregnancy body mass index (BMI) could mediate the associations between parental SES and SGA.MethodsThe participants of this study were pregnant women who enrolled in an ongoing birth cohort study, the Hokkaido study, during the first trimester of their pregnancies. A total of 14,593 live singleton births were included in the statistical analysis, of which 1011 (6.9%) were SGA. Two structural equation models were employed to evaluate the associations between parental SES, parental characteristics, and SGA.ResultsThe effect of low SES on SGA was directly mediated by maternal pre-pregnancy BMI, smoking during the third trimester, and alcohol consumption during the first trimester in the first model, which was based the assumption of independent associations between mediating factors. In the second model, which additionally considered the mediating factors from the first model, smoking during pregnancy mediated decline in parental SES, consequently increased SGA. Moreover, an increase in pregnancy smoking status increased the prevalence of lower maternal pre-pregnancy BMI and its effect on SGA.Conclusions for PracticeIn this study, we observed the independent mediating effect of maternal pre-pregnancy BMI, smoking, and alcohol consumption during pregnancy on low SES and, consequently, SGA, with the additional mediating pathway of SES to smoking to low BMI on SGA.