Apomorphine-induced penile erection and yawning: site of action in brain
Apomorphine-induced penile erection and yawning: site of action in brain
复制标题
阿朴吗啡引起的阴茎勃起和打哈欠：大脑中的作用部位
DOI：
10.1016/0006-8993(87)90272-1
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发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
G. Gessa
中科院分区：
文献类型：
--
作者：
M. R. Melis;A. Argiolas;G. Gessa
下丘脑室旁核微量注射多巴胺（DA）激动剂阿波啡诱导大鼠阴茎勃起和打哈欠。低至5纳克的阿波啡剂量就能引起显著的效果。症状通常在显微注射后5 min内开始，持续30-50 min，与全身给药诱导的症状相同。阿波啡显微注射PVN后，即使在最高剂量（1 μg）下也能观察到神经刻板和运动亢进。下丘脑腹内核、背内侧核、视前区、尾状核、伏隔核、黑质等部位显微注射相同剂量阿吗啡无效。特异性D2DA受体激动剂LY 171555和(+)-3-PPP，但不包括(−)-3-PPP和特异性D1DA受体激动剂SKF 38393，当注射到PVN时，与阿波啡一样有效。用氟哌啶醇、(−)-舒必利（一种特异性D2DA拮抗剂）和SCH 23390（一种特异性D1DA拮抗剂）等神经抑制药物预处理阿波吗啡诱导的阴茎勃起和打哈欠。目前的结果表明PVN是D2DA激动剂诱导阴茎勃起和打哈欠的脑区。此外，由于PVN包含一组神经下丘脑DA神经元的细胞体，上述结果首次表明，神经下丘脑DA系统可能参与了阴茎勃起和打哈欠的表达。
Microinjection of the dopamine (DA) agonist apomorphine into the paraventricular nucleus of the hypothalamus (PVN) induced penile erection and yawning in rats. A significant effect was elicited by a dose of apomorphine as low as 5 ng. The symptomatology usually began within 5 min after the microinjection, lasted for 30–50 min, and was identical to that induced by the systemic administration of the drug. Stereotypy and hypermotility were nerve observed after apomorphine microinjection into the PVN, even at the highest dose tested (1 μg). Microinjections of the same doses of apomorphine into the hypothalamic ventromedial and dorsomedial nucleus, preoptic area, caudate nucleus, nucleus accumbens and substantia and substantia nigra, were ineffective. LY 171555, a specific D2DA receptor agonist, and (+)-3-PPP, but not (−)-3-PPP nor the specific D1DA receptor agonist SKF 38393, were as effective as apomorphine when injected into the PVN. Apomorphine-induced penile erection and yawning were antagonized by pretreatment with neuroleptic drugs, such as haloperidol, (−)-sulpiride, a specific D2DA antagonist, and SCH 23390, a specific D1DA antagonist. The present results suggest that the PVN is the brain area where D2DA agonists act to induce penile erection and yawning. Moreover, since the PVN contains the cell bodies of a group of incertohypothalamic DA neurons, the above results suggest for the first time a possible involvement of the incerto-hypothalamic DA system in the expression of penile erection and yawning.