Enhancement of spatial learning by predator odor in mice: Involvement of amygdala and hippocampus
Enhancement of spatial learning by predator odor in mice: Involvement of amygdala and hippocampus
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DOI：
10.1016/j.nlm.2009.09.011
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发表时间：
2010-02-01
影响因子：
2.7
通讯作者：
Pourie, Gregory
中科院分区：
文献类型：
--
作者：
Galliot, Emmanuel;Levaillant, Maryline;Pourie, Gregory
与其他感觉线索相比，嗅觉与学习和记忆有着特殊的联系，这是由于它们的神经回路之间的相互关系。本研究探讨了一种假定的应激源（即捕食者气味）对小鼠视觉空间学习的影响。首先，研究结果表明，在Morris水迷宫任务中，捕食者气味的传播导致学习增强。此外，立体定位的方法被用来调查参与杏仁核在这类依赖于大脑皮层的学习。因此，在捕食者气味条件下的视觉空间学习的小鼠的性能显着降低了由鹅膏双侧杏仁核病变。杏仁核的参与证实了减少表达c-fos在海马CA 1区的杏仁核损伤小鼠在学习proceeding.Mild暴露于捕食者的气味，因此，通过共同激活的杏仁核，可能是由应激介导的机制，在学习过程中的依赖性learningcampus-dependent learning。(C)2009 Elsevier Inc. All rights reserved.
Olfaction has particular links with learning and memory compared with other sensory cues, due to the interrelations between their neural circuitry. The present study deals with the effects of a putative stressor (i.e. a predator odor) on visuo-spatial learning in mice. Firstly, the results show that a predator odor spread during the Morris water maze task led to learning enhancement. In addition, a stereotaxic approach was used to investigate the involvement of the amygdala in this hippocampus-dependent type of learning. Thus, the performance of mice in visuo-spatial learning under predator odor conditions was dramatically reduced by an ibotenate bilateral amygdala lesion. The involvement of the amygdala was confirmed by a reduced expression of c-fos in the CA1 hippocampus of amygdala-lesioned mice at the end of the learning procedure.Mild exposure to a predator odor during hippocampus-dependent learning therefore leads to an enhancement of performance through the co-activation of the amygdala, probably by a stress mediated mechanism. (C) 2009 Elsevier Inc. All rights reserved.