Amelioration of renal lesions associated with diabetes by dietary curcumin in streptozotocin diabetic rats
Amelioration of renal lesions associated with diabetes by dietary curcumin in streptozotocin diabetic rats
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DOI：
10.1023/a:1006821828706
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发表时间：
1998-04-01
影响因子：
4.3
通讯作者：
Srinivasan, K
中科院分区：
文献类型：
--
作者：
Babu, PS;Srinivasan, K
以常用香料姜黄（Curcuma longa）的着色原理，在日粮中添加0.5%的姜黄素，饲喂链脲佐菌素诱导的糖尿病Wistar大鼠8周。通过尿中排出的蛋白质量和肾小管酶（NAG、LDH、AsAT、AlAT、碱性和酸性磷酸酶）的浸出程度来评估肾脏损害。通过测定肾组织中葡萄糖-6-磷酸脱氢酶、葡萄糖-6-磷酸酶、LDH（碳水化合物代谢）、醛糖还原酶和山梨醇脱氢酶（多元醇途径）、转氨酶、atp酶和膜PUFA/SFA比值（膜完整性）的活性来评估肾脏的完整性。关于糖尿病患者的酶血症、蛋白尿、肾脏atp酶活性和肾膜脂肪酸组成的数据表明，饮食中的姜黄素对糖尿病肾脏病变的进展具有显著的有益调节作用。肾切片的组织学检查也证实了这些发现。由此推断，膳食姜黄素对糖尿病肾病的有益改善作用可能是通过其降低血胆固醇水平的能力介导的。
Curcumin, the coloring principle of the commonly used spice turmeric (Curcuma longa) was fed at 0.5% in the diet to streptozotocin-induced diabetic Wistar rats for 8 weeks. Renal damage was assessed by the amount of proteins excreted in the urine and the extent of leaching of renal tubular enzymes: NAG, LDH, AsAT, AlAT, alkaline and acid phosphatases. The integrity of kidney was assessed by measuring the activities of several key enzymes of the renal tissue: glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, and LDH (Carbohydrate metabolism), aldose reductase and sorbitol dehydrogenase (polyol pathway), transaminases, ATPases and membrane PUFA/SFA ratio (membrane integrity). Data on enzymuria, albuminuria, activity of kidney ATPases and fatty acid composition of renal membranes in diabetic condition suggested that dietary curcumin brought about significant beneficial modulation of the progression of renal lesions in diabetes. These findings were also corroborated by histological examination of kidney sections. It is inferred that this beneficial ameliorating influence of dietary curcumin on diabetic nephropathy is possibly mediated through its ability to lower blood cholesterol levels.