Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder
Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder
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DOI：
10.1159/000098262
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Lyoo, In Kyoon
中科院分区：
文献类型：
--
作者：
Kim, Seog Ju;Jeong, Do-Un;Lyoo, In Kyoon
之前，我们的研究小组在全脑探索中报道了创伤后应激障碍（PTSD）患者左前扣带白质束完整性的改变。目前的研究旨在探讨这种改变是否在任何特定的区域更突出。获取21例PTSD患者和21例健康对照者的弥散张量图像。八个感兴趣的等立方体区域（roi），即双侧吻侧，亚属，背侧和上扣带束，被选择。测量各组间脑白质束完整性的各向异性分数值。与对照组相比，PTSD受试者在吻侧、亚属和背侧带束的各向异性分数值显著减小（分别降低26.7%、25.0%和22.2%），而在右侧roi分数值则无显著差异。我们报告了创伤后应激障碍中扣带束的不对称改变。版权所有(c) 2006 S. Karger AG，巴塞尔。
Previously, our group reported the altered white matter tract integrity of the left anterior cingulate in posttraumatic stress disorder ( PTSD) in whole-brain exploration. Current study intended to explore whether the alteration was more prominent in any specific regions of the cingulum bundle. Diffusion tensor images of 21 PTSD subjects and 21 healthy comparison subjects were acquired. Eight isocubic regions of interest (ROIs), i.e. bilateral rostral, subgenual, dorsal, and upper cingulum bundle, were selected. Fractional anisotropy values in each ROI, which indicate the white matter tract integrity, were measured and compared between groups. Relative to comparison subjects, PTSD subjects had significantly smaller fractional anisotropy values in the left side of rostral, subgenual and dorsal cingulum bundle (26.7, 25.0, 22.2% decrease, respectively), but not in the right side ROIs. We report an asymmetrical alteration of the cingulum bundle in PTSD. Copyright (c) 2006 S. Karger AG, Basel.