Herpes simplex virus latency: the cellular location of virus in dorsal root ganglia and the fate of the infected cell following virus activation.
Herpes simplex virus latency: the cellular location of virus in dorsal root ganglia and the fate of the infected cell following virus activation.
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单纯疱疹病毒潜伏期：病毒在背根神经节中的细胞位置以及病毒激活后受感染细胞的命运。
DOI：
10.1099/0022-1317-51-2-233
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
G. Darby
中科院分区：
文献类型：
--
作者：
J. L. McLennan;G. Darby
外周接种HSV-1的ts突变体后，Balb/c小鼠颈背根神经节出现潜伏感染。在体外非允许温度下，通过切除的神经节培养或在体内通过神经外科手术激活突变体LS2，可以明确地确定该神经元是潜伏感染的部位。有证据表明，通过神经外科手术激活潜伏感染神经节的病毒感染可减少该神经节中潜伏病灶的数量。对这一观察结果的一种解释是，神经元中潜伏病毒激活后的生产性感染导致了该细胞的破坏。
Latent infections have been established in cervical dorsal root ganglia of Balb/c mice following peripheral inoculation of ts mutants of HSV-1. Activation of the mutant LS2 at the non-permissive temperature in vitro by culture of excised ganglia, or in vivo by neurosurgery has allowed the unambiguous identification of the neuron as the site of latent infection. Evidence is presented which shows that activation of virus infection in latently infected ganglia by neurosurgery results in a reduction of the number of latent foci in that ganglion. One interpretation of this observation is that the productive infection which follows activation of latent virus in the neuron leads to the destruction of that cell.