The burden of mental comorbidity in multiple sclerosis: frequent, underdiagnosed, and undertreated
The burden of mental comorbidity in multiple sclerosis: frequent, underdiagnosed, and undertreated
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DOI：
10.1177/1352458508099477
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发表时间：
2009-03-01
影响因子：
5.8
通讯作者：
Vollmer, T.
中科院分区：
文献类型：
--
作者：
Marrie, R. A.;Horwitz, R.;Vollmer, T.
背景精神共病在多发性硬化症(MS)中很常见，但一些研究表明，精神共病可能没有得到足够的认识和治疗。目的利用北美MS注册研究委员会，我们评估了多发性硬化症患者精神共病的频率以及与抑郁症的诊断和治疗相关的社会人口学特征。抑郁症状用流行病学研究中心抑郁量表(CESD)进行评估，得分为21分表示可能患有严重抑郁。结果4264名应答者中有4264名(48%)患有精神共病，抑郁最常见(4012名，46%)。在没有报告精神共病的参与者中，751人(16.2%)的CESD得分=21，表明未诊断为抑郁症。较低的社会经济地位与患抑郁症(收入15,000-30,000美元vs>；100,000美元或1.34美元；1.11-1.62美元)、未确诊抑郁症(收入15,000-30,000美元vs>；100,000美元或1.52美元；1.08-2.13美元)和未经治疗的抑郁症(
Background Mental comorbidity is common in multiple sclerosis (MS), but some studies suggest that mental comorbidity may be underrecognized and undertreated.Objective Using the North American Research Committee on MS Registry, we assessed the frequency of mental comorbidities in MS and sociodemographic characteristics associated with diagnosis and treatment of depression.Methods We queried participants regarding depression, anxiety, bipolar disorder, and schizophrenia. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CESD); a score >= 21 indicated probable major depression.Results Mental comorbidity affected 4264 (48%) responders; depression most frequently ( 4012, 46%). Among participants not reporting mental comorbidity, 751 (16.2%) had CESD scores = 21 suggesting undiagnosed depression. Lower socioeconomic status was associated with increased odds of depression (Income $15,000-30,000 vs >$100,000 OR 1.34; 1.11-1.62), undiagnosed depression (Income $15,000-30,000 vs >$100,000 OR 1.52; 1.08-2.13), and untreated depression (