Different effects of pravastatin and cerivastatin on the media of the carotid arteries as assessed by integrated backscatter ultrasound
Different effects of pravastatin and cerivastatin on the media of the carotid arteries as assessed by integrated backscatter ultrasound
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DOI：
10.1253/circj.68.784
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发表时间：
2004-08-01
影响因子：
3.3
通讯作者：
Fujiwara, H
中科院分区：
文献类型：
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作者：
Ito, Y;Kawasaki, M;Fujiwara, H
背景目前，有各种类型的他汀类药物用于治疗高脂血症和冠状动脉疾病。本研究的目的是使用背向散射积分（IB）超声比较亲脂性他汀类药物（西立伐他汀）与亲水性他汀类药物（普伐他汀）对颈动脉中膜的影响。方法和结果测定36例高脂血症患者在他汀类药物治疗或饮食治疗6个月前后72段颈动脉中膜IB值（C组，n=13; P组，n=12;饮食组，n=11）。另外，对34例无冠心病危险因素的患者进行了34段颈动脉IB值测定。同时用常规超声测量动脉内膜中层厚度（IMT）和动脉硬化度（stiffness beta）。P组的IB值没有显著变化（12.8+/-3.5 vs 12.7+/-2.7 dB），但C组降低（12.1+/-2.9 vs 10.0+/-2.7 dB，p
Background Currently, there are various types of statins used in the treatment of hyperlipidemia and coronary artery disease. The purpose of this study was to compare the effects of a lipophilic statin (cerivastatin) with those of a hydrophilic statin (pravastatin) on the carotid arterial media using integrated backscatter (IB) ultrasound. Cerivastatin (C) has a strong anti-proliferative effect (APE) on smooth muscle cells (SMCs), whereas pravastatin (P) has a weak effect.Methods and Results The IB values in the media of 72 segments of carotid arteries were measured in 36 patients with hyperlipidemia before and after statin therapy or diet for 6 months (C, n=13: P, n=12: diet, n=11). In addition, IB values of 34 segments of carotid arteries were measured in 34 patients without coronary risk factors. Intima-media thickness (IMT) and arterial stiffness (stiffness beta) were measured by conventional echo at the same time. IB values did not significantly change in the P group (12.8+/-3.5 vs 12.7+/-2.7 dB), but decreased in the C group (12.1+/-2.9 vs 10.0+/-2.7 dB, p