Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit.
Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit.
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DOI：
10.3389/fnsyn.2016.00032
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发表时间：
2016
影响因子：
3.7
通讯作者：
Mellor JR
中科院分区：
文献类型：
--
作者：
Prince LY;Bacon TJ;Tigaret CM;Mellor JR
海马体中的前馈齿状回-CA3 微电路被认为可以激活 CA3 锥体细胞和中间神经元的集合来编码和检索情景记忆。这些 CA3 整体的创建取决于该微电路内的神经调节输入和突触可塑性。在这里，我们回顾了神经调节剂乙酰胆碱、去甲肾上腺素、多巴胺和血清素重新配置该微电路的机制，从而推断这些调节剂对情景记忆编码和检索过程的净效应。
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.