Distribution of immunoglobulins during embryogenesis in the chicken.
Distribution of immunoglobulins during embryogenesis in the chicken.
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鸡胚胎发生过程中免疫球蛋白的分布。
DOI：
10.1111/j.1439-0442.1991.tb00986.x
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
U. Lösch
中科院分区：
文献类型：
--
作者：
B. Kaspers;I. Schranner;U. Lösch
而新鲜产下的鸡蛋的蛋黄只含有IgG，除了微量的伊加，我们能够测量，平均0.145毫克/毫升IgM和0.207毫克/毫升伊加的卵黄囊内容物的21日龄鸡胚。直到胚胎第14天，IgG仅包含在卵黄囊内容物中。通过比较新鲜产蛋和21日龄胚胎卵黄囊内容物中IgM和伊加的量，无法证明免疫球蛋白的量增加。实验诱导的无丙种球蛋白血症母鸡的后代直到孵化后才开始产生免疫球蛋白同种型IgG、IgM和伊加。从这些结果可以得出结论，免疫球蛋白IgM和伊加从鸡蛋白色转移到卵黄囊内容物在胚胎发育的最后三分之一。由于这项研究，这些免疫球蛋白的胚胎合成可以被忽略。发现IgG在出生后第2天和第7天之间开始合成，IgM在出生后第2天和第4天之间开始合成，伊加在出生后第6天和第13天之间开始合成。
Whereas the yolk of freshly-laid eggs contains only IgG, apart from traces of IgA, we were able to measure, on average, 0.145 mg/ml IgM and 0.207 mg/ml IgA in the yolk sac contents of 21-day-old chicken embryos. Up to the 14th embryonic day, IgG is exclusively contained in the yolk sac contents. It was not possible to demonstrate an increase in the amount of immunoglobulins present by comparing the amounts of IgM and IgA in freshly-laid eggs and in the yolk sac contents of 21-day-old embryos. The offspring of hens with experimentally-induced agammaglobulinemia did not begin with the production of the immunoglobulin isotypes IgG, IgM and IgA until after hatching. From these results the conclusion can be drawn that the immunoglobulins IgM and IgA are transferred from the egg white to the yolk sac contents during the last third of embryonic development. Embryonic synthesis of these immunoglobulins can be discounted as a result of this study. Synthesis was found to be initiated between the 2nd and 7th day of life for IgG, between the 2nd and 4th day of life for IgM and between the 6th and 13th day of life for IgA.