Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China.
Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China.
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DOI：
10.1186/1471-2334-13-322
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发表时间：
2013-07-15
影响因子：
3.7
通讯作者：
Ke C
中科院分区：
文献类型：
--
作者：
Li W;Yi L;Su J;Lu J;Zeng H;Guan D;Ma C;Zhang W;Xiao H;Li H;Zhang Y;Lin J;Ke C
手足口病是一种常见的儿科疾病。主要由肠道病毒71型和柯萨奇病毒A16型感染引起的手足口病暴发在东南亚地区频繁发生，已成为严重的公共卫生问题。目前，只有少数研究调查了中国手足口病的人体免疫力。在这项研究中，我们在中国广东省进行了一项队列研究。对10岁以下儿童的储存血清样本进行了分析。采用微量中和试验对2008年手足口病大爆发前、大爆发中及大爆发后不久的EV 71和CA 16特异性抗体水平进行了评价。计算并比较几何平均滴度（GMT）。统计学显著性以P < 0.05计。2007-2009年广东省EV 71和CA 16的血清阳性率数据显示，EV 71和CA 16在广东省持续流行。2009年的低阳性率与2010年前所未有的手足口病爆发密切相关。广东省1-3岁儿童EV 71和1-5岁儿童CA 16阳性率随年龄增长而增高。EV 71和CA 16抗体GMT也在这些年龄组中较高。所有上述发现表明这些年龄组的常见感染。在定期血清阳性率调查和未来的疫苗接种运动中，它们显然应被放在首位。
Hand, foot and mouth disease (HFMD) is a common pediatric illness. Mainly induced by the Enterovirus 71 and Coxsackievirus A 16 infections, the frequently occurred HFMD outbreaks have become a serious public health problem in Southeast Asia. Currently,only a few studies have investigated the human immunity to HFMD in China. In this study, we conducted a cohort study in Guangdong province, China. Stored serum samples from children less than 10 years old were analyzed. The levels of EV71 and CA16 specific antibodies before, during and shortly after the 2008 large outbreak of HFMD were evaluated by the microneutralization test. The geometric mean titer (GMT) was calculated and compared. Statistical significance was taken as P < 0.05. The seroprevalence data showed a continuous circulation of EV71 and CA16 in Guangdong province China in 2007–2009. The low positive rate in 2009 correlated well with the unprecedented outbreak of HFMD in 2010. Age related increase of seroprevalence was identified in 1–3 years old children for EV71 and in 1–5 years old children for CA16 in Guangdong province. High GMT of EV71 and CA16 antibody titers were also found for these age groups. All of the above findings indicated common infections for these age groups. And they should clearly be at the top of the priority in periodical seroprevalence survey and future vaccination campaign.