Understanding mucosal and microbial functionality of the female reproductive tract by metaproteomics: Implications for HIV transmission
Understanding mucosal and microbial functionality of the female reproductive tract by metaproteomics: Implications for HIV transmission
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DOI：
10.1111/aji.12977
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发表时间：
2018-08-01
影响因子：
3.6
通讯作者：
Burgener, Adam D.
中科院分区：
文献类型：
--
作者：
Berard, Alicia R.;Perner, Michelle;Burgener, Adam D.
女性生殖道的粘膜表面含有生理、免疫和微生物成分，它们共同构成了对生殖健康至关重要的功能性“粘膜系统”。任何这些组成部分的改变或失衡都可能对性传播感染（如艾滋病毒）的易感性产生重大后果。近年来，先进的系统生物学技术，如元蛋白质组学的出现，提供了新的工具集，研究粘膜系统。研究已经将改变的粘膜蛋白质组与许多HIV风险因素联系起来，包括粘膜炎症、细菌性阴道病、激素避孕药和用于HIV预防的抗逆转录病毒药物的功效降低。在本文中，我们将讨论元蛋白质组学如何用于研究粘膜系统组分，包括上皮屏障，炎症和微生物组，重点是哪些改变可能导致女性艾滋病毒传播风险增加。
The mucosal surface of the female genital tract contains physiological, immunological, and microbial components that collectively comprise a functioning "mucosal system" that is critical for reproductive health. Alterations or imbalances to any of these components can have significant consequences for susceptibility to sexually transmitted infections, such as HIV. In recent years the advent of advanced systems biology technologies, such as metaproteomics, has provided new toolsets to studying mucosal systems. Studies have linked an altered mucosal proteome to many HIV risk factors including mucosal inflammation, bacterial vaginosis, hormonal contraceptives, and reduced efficacy of antiretroviral drugs for HIV prevention. Herein we will discuss how metaproteomics has been used to study mucosal system components, including epithelial barriers, inflammation, and the microbiome, with a focus on what alterations may contribute to increased HIV transmission risk in women.