The cerebellum and olfaction in the aging brain: a functional magnetic resonance imaging study
The cerebellum and olfaction in the aging brain: a functional magnetic resonance imaging study
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DOI：
10.1016/s1053-8119(03)00276-3
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发表时间：
2003-09-01
期刊：
影响因子：
5.7
通讯作者：
Murphy, C
中科院分区：
文献类型：
--
作者：
Ferdon, S;Murphy, C
本研究利用功能磁共振成像（fMRI）研究了健康年轻人和老年人在嗅觉刺激下小脑不同区域的激活。10名年轻人和10名老年人使用1.5 tmr扫描仪成像。气味剂醋酸戊酯以12秒开、40秒关的周期输送。在整个扫描过程中，参与者在第一次检测到每个刺激间隔时按下按钮，然后在气味消失时按下第二次按钮。使用AFNI软件对图像进行处理。与年轻人相比，老年人的上半月小叶（第1小叶）和下半月小叶（第11小叶）的小脑激活明显减少，而上半月小叶是先前确定的气味处理感兴趣的三个区域中的两个。有趣的是，两组在第三感兴趣的区域，即后四边形小叶（VI）显示出相似的激活水平，尽管老年人比年轻人表现出更多的变化。先前的研究确定了这一区域与注意力有关，这可能反映了一种可能性，即由于嗅觉能力下降，从事嗅觉任务的老年人在这些任务所需的注意力需求程度上可能比年轻人表现出更大的变异性。(C) 2003 Elsevier Inc.所有航班预订。
The present study investigated activation of distinct cerebellar regions as a result of olfactory stimulation in healthy young and elderly adults using functional magnetic resonance imaging (fMRI). Ten young and 10 elderly adults were imaged using a 1.5-TMR scanner. The odorant amyl acetate was delivered in 12-s on, 40-s off cycles. Throughout the scan participants responded with a button press at first detection of each stimulus interval followed by a second button press upon odorant extinction. Images were processed with AFNI software. Elderly participants showed significantly decreased cerebellar activation in both the superior semilunar lobule (Crus 1) and the inferior semilunar lobule (Crus 11), two of three previously identified regions of interest for odor processing, compared to young adults. Interestingly, both groups showed similar levels of activation in the third region of interest, the posterior quadrangular lobule (VI), although the elderly showed more variability than the young did. Previous research identifying this area to be involved in attention may reflect the possibility that elderly adults engaged in olfactory tasks may show more variability than young participants in the degree of attentional demands needed for these tasks as a result of decreased olfactory abilities. (C) 2003 Elsevier Inc. All fights reserved.