Altered Intrinsic Neuronal Interactions in the Visual Cortex of the Blind
Altered Intrinsic Neuronal Interactions in the Visual Cortex of the Blind
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DOI：
10.1523/jneurosci.1625-13.2013
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发表时间：
2013-10-23
影响因子：
5.3
通讯作者：
Hipp, Joerg F.
中科院分区：
文献类型：
--
作者：
Hawellek, David J.;Schepers, Inga M.;Hipp, Joerg F.
在先天性失明中，大脑在严重的感觉剥夺下发育，并在结构和功能上经历显著的可塑性变化。视觉剥夺枕叶皮质区的组织学和形态学改变，并表现出显着的重塑功能状态：神经活动的绝对水平提高，并调制的非视觉感官刺激以及更高的认知过程。然而，这种改变的功能状态的神经机制在很大程度上仍然未知。在这里，我们表明，先天性失明的视觉皮层表现出频率特异性内在神经元相互作用的特征增益。我们研究了11名先天失明的人的振荡活动，并在休息时用脑磁图匹配视力控制受试者。我们发现，在盲人的视觉皮层中，δ波段（1-3 Hz）和γ波段（76-128 Hz）振荡的自发相关性增加。局部δ相位调制伽马振幅。此外，经典的静息节律（8-20 Hz）的振幅降低，但没有显示出改变的相关模式。我们的研究结果表明，减少抑制和电路机制，支持主动处理的内在功能改变的视觉皮层的功能状态在先天性失明的人。
In congenital blindness, the brain develops under severe sensory deprivation and undergoes remarkable plastic changes in both structure and function. Visually deprived occipital cortical regions are histologically and morphologically altered and exhibit a strikingly remodeled functional state: absolute levels of neural activity are heightened and are modulated by nonvisual sensory stimulation as well as higher cognitive processes. However, the neuronal mechanisms that underlie this altered functional state remain largely unknown. Here, we show that the visual cortex of the congenitally blind exhibits a characteristic gain in frequency-specific intrinsic neuronal interactions. We studied oscillatory activity in 11 congenitally blind humans and matched sighted control subjects with magnetoencephalography at rest. We found increased spontaneous correlations of delta band (1-3 Hz) and gamma band (76-128 Hz) oscillations across the visual cortex of the blind that were functionally coupled. Local delta phase modulated gamma amplitude. Furthermore, classical resting rhythms (8-20 Hz) were reduced in amplitude but showed no altered correlation pattern. Our results suggest that both decreased inhibition and circuit mechanisms that support active processing are intrinsic features underlying the altered functional state of the visual cortex in congenitally blind individuals.