Proximity of Cellular and Physiological Response Failures in Sepsis
Proximity of Cellular and Physiological Response Failures in Sepsis
复制标题
脓毒症中细胞和生理反应失败的相似性
DOI：
10.1109/jbhi.2021.3098428
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发表时间：
2021
影响因子：
7.7
通讯作者：
Yang, Christopher C.
中科院分区：
文献类型：
--
作者：
Jazayeri, Ali;Capan, Muge;Ivy, Julie;Arnold, Ryan;Yang, Christopher C.
脓毒症是一种破坏性的多阶段健康状况，死亡率很高。它的复杂性、普遍性以及其结果对早期检测的依赖性引起了数据科学和机器学习界的极大关注。以前的研究依赖于代表器官系统衰竭的个体细胞和生理反应来预测健康结果或不同脓毒症阶段的发病。然而，众所周知，器官系统的故障和动力学并不是独立的事件。在这项研究中，我们使用2013年7月至2015年12月期间住院的12,223名成人患者的数据，确定了与脓毒症相关的重大近端细胞和生理反应失败的依赖模式。结果表明，与个体反应相比，细胞和生理反应的近似性故障产生了更好的结果预测特征集。我们的发现揭示了在预测患者预后方面发挥主要作用的少数重大的近期失败。这项研究的结果可以简单地转化为临床实践，并为预测和改善患者的状况和结果提供信息。
Sepsis is a devastating multi-stage health condition with a high mortality rate. Its complexity, prevalence, and dependency of its outcomes on early detection have attracted substantial attention from data science and machine learning communities. Previous studies rely on individual cellular and physiological responses representing organ system failures to predict health outcomes or the onset of different sepsis stages. However, it is known that organ systems’ failures and dynamics are not independent events. In this study, we identify the dependency patterns of significant proximate sepsis-related failures of cellular and physiological responses using data from 12,223 adult patients hospitalized between July 2013 and December 2015. The results show that proximate failures of cellular and physiological responses create better feature sets for outcome prediction than individual responses. Our findings reveal the few significant proximate failures that play the major roles in predicting patients’ outcomes. This study's results can be simply translated into clinical practices and inform the prediction and improvement of patients’ conditions and outcomes.