Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development
Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development
复制标题
DOI：
10.1007/s004270100140
复制
发表时间：
2001-04-01
影响因子：
2.4
通讯作者：
Simons, JP
中科院分区：
文献类型：
--
作者：
Al-Shawi, R;Ashton, SV;Simons, JP
Ror 1和Ror 2是孤儿受体酪氨酸激酶，与神经营养因子受体的MuSK和Trk家族最密切相关。我们报告了这些基因在小鼠发育过程中表达的广泛原位杂交调查的结果。Ror 1和Ror 2的表达在早期阶段（E8.5-E9.5）显著不同。在这些时候，Ror 2的表达比Ror 1广泛得多，其表达主要限于头部间充质。在发育的后期（E12.5-E14.5），Ror 1的表达扩大，Ror 2的表达变得比早期更受限制。尽管Ror 1的表达仍然比Ror 2的表达更受限制。这些变化导致重叠的表达结构域，但仍存在主要差异。在许多情况下，Ror 1在Ror-2表达组织的子集中表达;在其他情况下，存在Ror 1和Ror 2的互补表达。Ror 1和Ror 2都在所有三个胚层的衍生物中表达，并且在大多数器官系统中表达，包括神经系统、循环系统、呼吸系统、消化系统、泌尿生殖系统和骨骼系统。显著性主位是主要感觉器官、神经嵴及其衍生物的表达。
Ror1 and Ror2 are orphan receptor tyrosine kinases that are most closely related to MuSK and the Trk family of neurotrophin receptors. We report the re suits of an extensive in situ hybridisation survey of the expression of these genes during mouse development. Expression of Ror1 and Ror2 differs markedly at early stages (E8.5-E9.5). At these times, Ror2 is expressed much more widely than Ror1, expression of which is largely restricted to head mesenchyme. At later stages of development (E12.5-E14.5), Ror1 expression expands and Ror2 expression becomes more restricted than at earlier times? although expression of Ror1 continues to be more restricted than that of Ror2. These changes result in overlapping expression domains but with major differences remaining. In many cases Ror1 is expressed in a sub-set of Ror-2-expressing tissues; in others, there is complementary expression of Ror1 and Ror2. Ror1 and Ror2 are both expressed in derivatives of all three germ layers and in most organ systems, including the nervous, circulatory, respiratory, digestive, urogenital and skeletal systems. Conspicuous themes are the expression in major sense organs, and in neural crest and its derivatives.