Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China
Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China
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DOI：
10.3760/cma.j.issn.0366-6999.2009.13.002
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发表时间：
2009-07-05
影响因子：
6.1
通讯作者：
Zhan Wen-hua
中科院分区：
文献类型：
--
作者：
Song Wu;Wu Sui-jing;Zhan Wen-hua
背景以往的研究表明，结直肠粘液腺癌、印戒细胞腺癌或非粘液腺癌患者的临床病理特征与预后之间的关系存在相互矛盾的结果;在中国进行的此类研究很少。本回顾性研究分析了我科的数据，以探讨三种组织学类型-结直肠粘液腺癌、印戒细胞腺癌和非粘液腺癌的临床病理特征、预后和可能的相关性，以阐明观察到的差异的基础，这些差异可能导致靶向治疗的发展。粘液腺癌144例，印戒细胞腺癌25例，非粘液腺癌1837例。结果粘液腺癌和印戒细胞腺癌好发于年轻患者（P
Background Previous studies have shown conflicting results on the relation between clinicopathologic features and prognosis of patients with colorectal mucinous, signet-ring cell, or non-mucinous adenocarcinoma; only few such studies have been performed in China. This retrospective study analyzed data from our department to investigate clinicopathologic characteristics, prognosis and possible correlations of three histologic types - colorectal mucinous, signet-ring cell, and non-mucinous adenocarcinoma, to clarify the bases for observed differences which may lead to development of targeted therapiesMethods Of 2079 patients diagnosed with colorectal cancer between 1994 and 2007, 144 had mucinous, 25 had signet-ring cell, and 1837 had non-mucinous adenocarcinoma. Their clinicopathologic parameters and survival were analyzed using established statistical methodologies.Results Mucinous and signet-ring cell adenocarcinomas were common in younger patients (P