Association of miRNA-146a Gene Polymorphism Rs2910164 with Behcet's Disease: A Meta-analysis
Association of miRNA-146a Gene Polymorphism Rs2910164 with Behcet's Disease: A Meta-analysis
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miRNA-146a 基因多态性 Rs2910164 与白塞氏病的关联：荟萃分析
DOI：
10.1080/09273948.2021.1968002
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发表时间：
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影响因子：
3.3
通讯作者：
Du Liping
中科院分区：
文献类型：
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作者：
Shan Jiankang;Zhou Pengyi;Liu Zhenzhen;Zheng Kaifeng;Jin Xuemin;Du Liping
背景通过总结相关研究进行荟萃分析，评估miRNA-146a基因多态性rs2910164与白塞病（BD）之间的关系。方法系统检索PubMed和Embase中已发表的研究。目前的荟萃分析中纳入了五项符合条件的研究，涉及 1167 例 BD 病例和 1662 例对照。 结果结果表明，在所有遗传模型中，rs2910164 多态性与 BD 易感性相关。在按种族进行的亚组分析中，这种多态性与BD之间的关系在白种人中更为显着（等位基因模型：OR = 0.49，95% CI 0.39-0.61；杂合子模型：OR = 0.35，95% CI 0.26-0.47；纯合子模型：OR = 0.29，95% CI 0.16-0.53；显性模型：OR = 0.29，95% CI 0.16-0.53；模型：OR = 0.34，95% CI 0.25–0.45；隐性模型：OR = 0.56，95% CI 0.50–0.72) 高于亚洲人。 结论 总之，这项荟萃分析表明 miRNA-146a 基因多态性 rs2910164 G 等位基因赋予 BD 易感性，尤其是在白种人中。
BackgroundA meta-analysis was performed by summarizing relevant researches to evaluate the relationship between miRNA-146a gene polymorphism rs2910164 and Behcet’s disease (BD).MethodsA systematic search of published studies was conducted in PubMed and Embase. Five eligible studies involving 1167 BD cases and 1662 controls were included in the current meta-analysis.ResultsThe results suggested that the polymorphism rs2910164 was correlated with BD susceptibility in all genetic models. In subgroup analysis according to ethnicity, the relationship between this polymorphism and BD was more significant in Caucasians (allele model: OR = 0.49, 95% CI 0.39–0.61; heterozygote model: OR = 0.35, 95% CI 0.26–0.47; homozygote model: OR = 0.29, 95% CI 0.16–0.53; dominant model: OR = 0.34, 95% CI 0.25–0.45; recessive model: OR = 0.56, 95% CI 0.50–0.72) than that in Asians.ConclusionIn conclusion, this meta-analysis indicates that miRNA-146a gene polymorphism rs2910164 G allele confers BD susceptibility, especially in Caucasians.