Emerging phytochemicals for prevention of melanoma invasion.

Emerging phytochemicals for prevention of melanoma invasion.
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DOI:
10.1016/j.canlet.2013.02.056
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发表时间:
2013-07-28
期刊:
影响因子:
9.7
通讯作者:
Katiyar, Santosh K.
Katiyar, Santosh K.
中科院分区:
医学1区
文献类型:
--
作者:
Jones, Virginia;Katiyar, Santosh K.

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皮肤恶性黑色素瘤是皮肤疾病死亡的主要原因,因为它的倾向转移。一旦被诊断为转移性黑色素瘤,大多数患者将在2年内死于疾病。由于抑制转移需要长期干预,因此潜在的抗转移药物不仅必须有效,而且必须具有低毒性。传统医学中使用的许多植物化学物质毒性较低,最近的研究表明,其中一些有希望用于预防或治疗转移性黑色素瘤。在这里,我们回顾了最近关于植物化学物质对黑色素瘤细胞迁移或侵袭的抑制作用的文献。
Cutaneous malignant melanoma is the leading cause of death from skin diseases due to its propensity to metastasize. Once diagnosed with metastatic melanoma, most patients will die of their disease within 2 years. As suppression of metastases requires long-term interventions, potential anti-metastatic agents must not only be efficacious but also have low toxicity. Many phytochemicals used in traditional medicine have low toxicity and recent studies suggest that some are promising candidates for the prevention or treatment of metastatic melanoma. Here, we review the recent literature regarding phytochemicals that have shown inhibitory effects on melanoma cell migration or invasion.
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