Orosensory responsiveness to and preference for hydroxide-containing salts in mice.
Orosensory responsiveness to and preference for hydroxide-containing salts in mice.
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小鼠对含氢氧化物盐的口腔感觉反应和偏好。
DOI：
10.1093/chemse/bjp023
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发表时间：
2009
期刊：
影响因子：
3.5
通讯作者：
BoughterJr,JohnD
中科院分区：
文献类型：
--
作者：
StJohn,StevenJ;BoughterJr,JohnD
在历史上，味觉研究人员曾考虑过味觉系统检测到碱性化合物的可能性，例如那些含有氢氧化物离子的化合物，但证据并不充分。我们发现，在48小时的两瓶偏爱实验中，C3HeB/FEJ(C3)小鼠表现出对Ca(OH)2的偏爱，而SWR/J(Sw)小鼠则表现出回避。NaOH的菌株差异也很明显，但CaCl2的差异不明显。后续研究表明，Ca(OH)2的菌株差异随着时间的推移是稳定的(实验2)，但在简短访问测试中，C3和SW小鼠对Ca(OH)2或NaOH的反应没有差异，两只小鼠都避免了高浓度的这些化合物(实验3)。为了评估氢氧化钙的感知质量，对小鼠进行了两个味觉厌恶概括实验(实验4和实验5)。对Ca(OH)2的厌恶在两个菌株中都概括为NaOH，而不是CaCl2，这表明这种概括是基于氢氧化物离子。这两个菌株还概括了对奎宁的厌恶，这表明氢氧化物离子对这些小鼠有苦味的可能性，尽管C3小鼠在长期测试中表现出对中等浓度的偏爱。
Historically, taste researchers have considered the possibility that the gustatory system detects basic compounds, such as those containing the hydroxide ion, but evidence for an “alkaline taste” has not been strong. We found that, in 48 h, 2-bottle preference tests, C3HeB/FeJ (C3) mice showed a preference for Ca(OH)2, whereas SWR/J (SW) mice showed avoidance. Strain differences were also apparent to NaOH but not CaCl2. Follow-up studies showed that the strain difference for Ca(OH)2was stable over time (Experiment 2) but that C3 and SW mice did not differ in their responses to Ca(OH)2or NaOH in brief-access tests, where both mice avoided high concentrations of these compounds (Experiment 3). In order to assess the perceived quality of Ca(OH)2, mice were tested in 2 taste aversion generalization experiments (Experiments 4 and 5). Aversions to Ca(OH)2generalized to NaOH but not CaCl2in both strains, suggesting that the generalization was based on the hydroxide ion. Both strains also generalized aversions to quinine, suggesting the possibility that the hydroxide ion has a bitter taste quality to these mice, despite the preference shown by C3 mice to middle concentrations in long-term tests.