Reversible associative depression and nonassociative potentiation at a parallel fiber synapse
Reversible associative depression and nonassociative potentiation at a parallel fiber synapse
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DOI：
10.1016/s0896-6273(00)00070-2
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发表时间：
2000-09-01
期刊：
影响因子：
16.2
通讯作者：
Bell, CC
中科院分区：
文献类型：
--
作者：
Han, VZ;Grant, K;Bell, CC
电鱼的电感觉袍（electrosensory robe，ELL）是鱼类中几种小脑样感觉结构之一，可以消除感觉流入的可预测特征。这种适应性过程遵守反赫布规则，并似乎是由平行纤维和浦肯野样细胞的ELL之间的突触的关联抑制介导的。我们在这里表明，也有一个nonassociative potentiation在这个突触，只依赖于EPSP的重复发生。抑制可以通过增强来逆转，反之亦然。最后，我们表明，关联抑郁症需要NMDA受体激活，突触后钙的变化，并在几毫秒内发生的突触后树突棘以下EPSP发病。
The electrosensory robe (ELL) of mormyrid electric fish is one of several cerebellum-like sensory structures in fish that remove predictable features of the sensory inflow. This adaptive process obeys anti-Hebbian rules and appears to be mediated by associative depression at the synapses between parallel fibers and Purkinje-like cells of ELL. We show here that there is also a nonassociative potentiation at this synapse that depends only on the repeated occurrence of the EPSP. The depression can be reversed by the potentiation and vice versa. Finally, we show that the associative depression requires NMDA receptor activation, changes in postsynaptic calcium, and the occurrence of a postsynaptic dendritic spike within a few milliseconds following EPSP onset.