No Associations Between Telomere Length and Age-Sensitive Indicators of Physical Function in Mid and Later Life
No Associations Between Telomere Length and Age-Sensitive Indicators of Physical Function in Mid and Later Life
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DOI：
10.1093/gerona/glq050
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发表时间：
2010-08-01
影响因子：
5.1
通讯作者：
Christensen, Helen
中科院分区：
文献类型：
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作者：
Mather, Karen Anne;Jorm, Anthony Francis;Christensen, Helen
端粒长度随着年龄的增长而下降，已经被假设为生物衰老的指标。如果它实现了这一目的，较短的端粒长度应该与年龄相关的身体功能丧失相关，而与年龄无关。在这项横断面澳大利亚人群研究中，在两个年龄范围较窄的队列（44-49岁（n = 351）和64-70岁（n = 295））中检查了外周血白细胞端粒长度与身体功能（肺功能、血压和握力）的年龄敏感指标之间的相关性。端粒长度与收缩压相关，但仅适用于年轻队列的女性，并且与预期方向相反（部分r = 0.181，p = 0.017）。这一证据并不支持端粒长度与年龄相关的身体功能变化有关的假设。
Telomere length, which declines with age, has been hypothesized to act as an indicator of biological aging. If it fulfills this purpose, shorter telomere length should correlate with age-related loss of physical function, independent of age. In this cross-sectional Australian population study, the associations between peripheral blood leukocyte telomere length and age-sensitive indicators of physical function (lung function, blood pressure, and grip strength) were examined in two narrow age range cohorts aged 44-49 years (n = 351) and 64-70 years (n = 295). Telomere length was correlated with systolic blood pressure but only for women of the younger cohort and in the opposite direction to that expected (partial r = .181, p = .017). This evidence does not provide support for the hypothesis that telomere length is related to age-associated changes in physical function.