Alterations of mature arterioles associated with chronically reduced blood flow.
Alterations of mature arterioles associated with chronically reduced blood flow.
复制标题
与长期血流量减少相关的成熟小动脉的改变。
DOI：
10.1152/ajpheart.1993.264.1.h40
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Prewitt,RL
中科院分区：
文献类型：
--
作者：
Wang,DH;Prewitt,RL
成熟的小动脉的适应性反应进行了检查后，总血流量减少38%的提睾肌产生的单侧睾丸切除术在12周龄的大鼠。四周后，肌肉小于对侧提睾肌，在此期间，提睾肌的大小没有增加。通过闭路电视显微镜测量，第一至第四级小动脉（1A-4A）的内径较小，但仅在3A中壁横截面积减小。小直径的1A在小脑扁桃体切除肌肉导致不变的壁剪切率。从灌注固定，微填充提睾肌，拱状小动脉的总长度和3A的数量没有统计学差异，但4A的总数量显着减少的睾丸切除侧。因此，在成熟肌肉中的慢性负荷减少导致血流量减少，4A的数量减少，以及在血管壁横截面积没有净变化的情况下小动脉内径变小。一个局部的自动调节机制有关的流动诱导的剪切应力的机制介导的变化。
Adaptive responses of mature arterioles were examined after a 38% reduction in total blood flow to the cremaster muscle produced by unilateral orchidectomy in 12-wk-old rats. Four weeks later, the muscle was smaller than the contralateral cremaster, which did not increase in size during this period. Measured by closed-circuit television microscopy, the internal diameters of first- through fourth-order arterioles (1A-4A) were smaller, but wall cross-sectional area was reduced only in 3As. The smaller diameter of the 1A in the orchidectomy muscle resulted in unchanged wall shear rate. As determined from the perfusion-fixed, microfilled cremaster muscles, the total length of the arcading arterioles and the number of 3As were not statistically different, but the total number of 4As was significantly reduced on the orchidectomy side. Therefore, chronic load reduction in a mature muscle resulted in reduced blood flow, decreased number of 4As, and smaller arteriolar internal diameters in the absence of net changes in vascular wall cross-sectional area. A local autoregulatory mechanism related to flow-induced shear stress is suggested as the mechanism mediating the changes.