Respiratory deposition of ultrafine welding fume particles
Respiratory deposition of ultrafine welding fume particles
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DOI：
10.1080/15459624.2019.1652306
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发表时间：
2019-08-26
影响因子：
2
通讯作者：
Wang, Jun
中科院分区：
文献类型：
--
作者：
Su, Wei-Chung;Chen, Yi;Wang, Jun
焊接产生的超细颗粒吸入和沉积在焊工的呼吸道中与严重的肺部损伤有关。本文研制了一种移动式气溶胶肺沉积仪（MALDA），用于研究超细焊接烟尘颗粒的呼吸沉积。MALDA是用高分辨率3D打印机制作的一组具有生理代表性的人类气管支气管气道复制品构建的。在焊接烟尘室中产生超细焊接烟尘颗粒，并将其输送到MALDA。利用MALDA进行了一系列呼吸沉积实验，研究了超细焊接烟尘颗粒在不同气道代的气管支气管中的沉积情况。结果表明，利用MALDA可以方便、系统地测量焊接烟尘颗粒在人体气管支气管中沉积到第9代的情况。据估计，直径在10至100纳米之间的超细焊接烟尘颗粒的累积呼吸沉积约为9-31%。结果表明，所开发的MALDA在未来有可能成为一种有用的仪器，用于估计超细颗粒在实际工作场所的呼吸沉积。
The inhalation and the deposition of welding-generated ultrafine particles in welders' respiratory tracts have been linked to severe pulmonary impairments. In the present study, a mobile aerosol lung deposition apparatus (MALDA) was developed and applied to study the respiratory deposition of ultrafine welding fume particles. The MALDA was constructed with a set of physiologically representative human tracheobronchial airway replicas made with high-resolution 3D printers. Ultrafine welding fume particles were generated in a welding fume chamber and delivered to the MALDA. A series of respiratory deposition experiments were carried out using the MALDA to investigate the deposition of ultrafine welding fume particles in different airway generations of the tracheobronchial airways. The results showed that the fractional deposition of ultrafine welding fume particle in the human tracheobronchial airways down to the 9(th) airway generation could be readily and systematically measured by the MALDA. The estimated cumulative respiratory deposition ranged from approximately 9-31% for ultrafine welding fume particles between 10 and 100 nm in diameter. The results acquired demonstrated that the MALDA developed has the potential to become a useful apparatus in the future to estimate the respiratory deposition of ultrafine particles in real workplaces.