Redefining the identity of cardiac fibroblasts.
Redefining the identity of cardiac fibroblasts.
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DOI：
10.1038/nrcardio.2017.57
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Molkentin JD
中科院分区：
文献类型：
--
作者：
Tallquist MD;Molkentin JD
心脏成纤维细胞在器官发生和生理条件下沉积和维持细胞外基质。在成人心脏，活化的心脏成纤维细胞也参与急性心肌梗死后的愈合反应，以及以间质纤维化和心室重构为特征的慢性病状态。然而，心脏成纤维细胞的特性、可塑性和起源的描述是一个正在进行的研究和争议的领域。已经开发了一套遗传小鼠模型，专门研究这些细胞的性质，包括它们的来源和在心脏病和心室重塑期间的反应。随着我们对心脏成纤维细胞的了解变得更加明确和精细，开发新的治疗策略来控制纤维化和不良的心室重构的可能性也越来越大。
Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and under physiological conditions. In the adult heart, activated cardiac fibroblasts also participate in the healing response after acute myocardial infarction and during chronic disease states characterized by augmented interstitial fibrosis and ventricular remodelling. However, delineation of the characteristics, plasticity, and origins of cardiac fibroblasts is an area of on-going investigation and controversy. A set of genetic mouse models has been developed that specifically addresses the nature of these cells, in terms of both their origins and their response during cardiac disease and ventricular remodelling. As our understanding of cardiac fibroblasts becomes more defined and refined, so does the potential to develop new therapeutic strategies to control fibrosis and adverse ventricular remodelling.
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影响因子：
23.9
作者：
Guimarães-Camboa N;Cattaneo P;Sun Y;Moore-Morris T;Gu Y;Dalton ND;Rockenstein E;Masliah E;Peterson KL;Stallcup WB;Chen J;Evans SM
通讯作者：
Evans SM
DOI：
10.1152/ajpheart.00514.2007
发表时间：
2007-09-01
影响因子：
4.8
作者：
Banerjee, Indroneal;Fuseler, John W.;Baudino, Troy A.
通讯作者：
Baudino, Troy A.
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5
作者：
Duim, Sjoerd N.;Kurakula, Kondababu;Kruithof, Boudewijn P. T.
通讯作者：
Kruithof, Boudewijn P. T.
影响因子：
3
作者：
Clausen, BE;Burkhardt, C;Förster, I
通讯作者：
Förster, I
影响因子：
15.3
作者：
GABBIANI, G;RYAN, GB;STATKOV, PR;HIRSCHEL, BJ;MAJNO, G
通讯作者：
MAJNO, G