Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease
Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease
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DOI：
10.1093/eurheartj/ehi190
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发表时间：
2005-05-01
影响因子：
39.3
通讯作者：
Tardif, JC
中科院分区：
文献类型：
--
作者：
Diaz, A;Bourassa, MG;Tardif, JC
降低心率是心绞痛治疗的基石。本研究的目的是探讨稳定型冠状动脉疾病（CAD）患者心率的预后价值。方法和结果我们评估了基线静息心率与心血管死亡率/发病率之间的关系，同时调整了危险因素。对来自冠状动脉手术研究登记处的共24913例疑似或确诊CAD的患者进行了中位随访14.7年的研究。全因死亡率、心血管死亡率和心血管再住院率随心率增加而增加（P < 0.0001）。基线时静息心率≥ 83 bpm的患者在校正多个临床变量后，总死亡率[风险比（HR）= 1.32，CI 1.19-1.47，P < 0.0001]和心血管死亡率（HR = 1.31，CI 1.15-1.48，P < 0.0001）的风险显著高于参考组。当比较心率在77-82和>= 83 bpm之间的患者与心率在10 - 15 bpm之间的患者时，
Aims Heart rate reduction is the cornerstone of the treatment of angina. The purpose of this study was to explore the prognostic value of heart rate in patients with stable coronary artery disease (CAD).Methods and results We assessed the relationship between resting heart rate at baseline and cardiovascular mortality/morbidity, while adjusting for risk factors. A total of 24913 patients with suspected or proven CAD from the Coronary Artery Surgery Study registry were studied for a median follow-up of 14.7 years. All-cause and cardiovascular mortality and cardiovascular rehospitalizations were increased with increasing heart rate (P < 0.0001). Patients with resting heart rate >= 83 bpm at baseline had a significantly higher risk for total mortality [hazard ratio (HR) = 1.32, Cl 1.19-1.47, P < 0.0001] and cardiovascular mortality (HR = 1.31, Cl 1.15-1.48, P < 0.0001) after adjustment for multiple clinical variables when compared with the reference group. When comparing patients with heart rates between 77-82 and >= 83 bpm with patients with a heart rate