An integrated multichannel waveform generator for large-scale spatio-temporal stimulation of neural tissue
An integrated multichannel waveform generator for large-scale spatio-temporal stimulation of neural tissue
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DOI：
10.1007/s10470-007-9125-x
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发表时间：
2008-06-01
影响因子：
1.4
通讯作者：
Wiacek, Piotr
中科院分区：
文献类型：
--
作者：
Hottowy, Pawel;Dabrowski, Wtadystaw;Wiacek, Piotr
我们提出了一个专用集成电路设计的电刺激神经组织使用多电极阵列。ASIC预计将应用于需要同时刺激和记录体外和体内各种类型神经组织信号的系统中。开发的ASIC包括64个独立的刺激通道，能够产生任意定义的双极电流或电压波形，以真实的时间控制，时间分辨率为12.5 μ s，幅度分辨率为7位。输出信号的幅度范围可以在非常宽的范围内缩放，这确保了与不同尺寸和几何形状的各种电极阵列的兼容性。每个通道还配备了一个真实的时间控制的刺激伪影抑制器，它减少了每个刺激脉冲后系统的死区时间。
We present an ASIC designed for electrical stimulation of neural tissue using multielectrode arrays. The ASIC is foreseen for applications in systems that require simultaneous stimulation and recording of signals from various types of neural tissue, both in vitro and in vivo. The developed ASIC comprises 64 independent stimulation channels, which are capable to generate arbitrarily defined bipolar current or voltage waveforms, controlled in real time with time resolution of 12.5 mu s and amplitude resolution of 7 bits. The amplitude range of output signal can be scaled over a very wide range, which ensures compatibility with various electrode arrays of different size and geometry. Each channel is also equipped with a stimulation artifact suppressor controlled in real time, which reduces the dead time of the system after each stimulation pulse.