X-ray refraction effects: application to the imaging of biological tissues
X-ray refraction effects: application to the imaging of biological tissues
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DOI：
10.1259/bjr/32889803
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发表时间：
2003-05-01
影响因子：
2.6
通讯作者：
Rogers, KD
中科院分区：
文献类型：
--
作者：
Lewis, RA;Hall, CJ;Rogers, KD
本研究的目的是探索生物组织的折射对比X射线成像的潜力。在意大利的里雅斯特的Elettra同步加速器上，使用医用光束线产生了解剖的小鼠肺、心脏、肝脏和腿的图像。所使用的技术是衍射增强成像。这利用位于组织样本和检测器之间的硅晶体，通过布拉格衍射将折射的X射线与透射和散射的辐射分离。所产生的图像的对比度与组织的X射线折射率的变化有关，与基于吸收效应的传统X射线图像相比，其清晰度非常高。这些变化在不同组织之间的边界处最大，使图像具有明显的边缘增强效果和三维外观。该技术提供了一种对尚未开发的生物组织特性进行成像的方法，并计划进行进一步的研究以确定医学成像中的具体应用。
The purpose of this study was to explore the potential of refraction contrast X-ray imaging of biological tissues. Images of dissected mouse lungs, heart, liver and legs were produced using the medical beamline at the Elettra Synchrotron at Trieste, Italy. The technique used was diffraction enhanced imaging. This utilizes a silicon crystal positioned between the tissue sample and the detector to separate refracted X-rays from transmitted and scattered radiation by Bragg diffraction. The contrast in the images produced is related to changes in the X-ray refractive index of the tissues, resulting in remarkable clarity compared with conventional X-ray images based on absorption effects. These changes were greatest at the boundaries between different tissues, giving a marked edge enhancement effect and three-dimensional appearance to the images. The technique provides a way of imaging a property of biological tissues not yet exploited, and further studies are planned to identify specific applications in medical imaging.