Phytoestrogen consumption and breast cancer risk in a multiethnic population - The Bay Area Breast Cancer Study
Phytoestrogen consumption and breast cancer risk in a multiethnic population - The Bay Area Breast Cancer Study
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DOI：
10.1093/aje/154.5.434
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发表时间：
2001-09-01
影响因子：
5
通讯作者：
Perez-Stable, EJ
中科院分区：
文献类型：
--
作者：
Horn-Ross, PL;John, EM;Perez-Stable, EJ
植物雌激素与乳腺癌风险之间关系的研究范围有限。大多数流行病学研究都涉及亚洲妇女，并检查了传统大豆食品（如豆腐）、大豆蛋白或植物雌激素尿液排泄的影响。本研究通过研究一系列植物雌激素化合物对非亚裔美国女性乳腺癌风险的影响，扩展了这一研究。研究人员将1995年至1998年间被诊断为乳腺癌的年龄在35岁至79岁之间的非裔美国人、拉丁裔和白人女性与通过随机拨号从普通人群中选择的女性进行比较。对1326例病例和1657例对照进行了访谈。通过食物频率问卷和新开发的营养数据库评估了特定植物雌激素化合物的通常摄入量。植物雌激素摄入与乳腺癌风险无关（优势比= 10,95%可信区间：0.80，最高四分位数对最低四分位数的比值为1.3）。绝经前和绝经后妇女、各种族妇女以及所有7种植物雌激素化合物的研究结果相似。植物雌激素在非亚裔美国女性通常摄入的水平上似乎对乳腺癌风险影响不大：平均摄入量相当于低于。每周吃一份豆腐。
Research on the relation between phytoestrogens and breast cancer risk has been limited in scope. Most epidemiologic studies have involved Asian women and have examined the effects of traditional soy foods (e.g., tofu), soy protein, or urinary excretion of phytoestrogens. The present study extends this research by examining the effects of a spectrum of phytoestrogenic compounds on breast cancer risk in non-Asian US women. African-American, Latina, and White women aged 35-79 years, who were diagnosed with breast cancer between 1995 and 1998, were compared with women selected from the general population via random digit dialing. Interviews were conducted with 1,326 cases and 1,657 controls. Usual intake of specific phytoestrogenic compounds was assessed via a food frequency questionnaire and a newly developed nutrient database. Phytoestrogen intake was not associated with breast cancer risk (odds ratio=1 0, 95% confidence interval: 0.80, 1.3 for the highest vs. lowest quartile). Results were similar for pre- and postmenopausal women, for women in each ethnic group, and for all seven phytoestrogenic compounds studied. Phytoestrogens appear to have little effect on breast cancer risk at the levels commonly consumed by non-Asian US women: an average intake equivalent to less than. one serving of tofu per week.