Effect of increased intracardiac and arterial pressure on plasma vasopressin in humans.
Effect of increased intracardiac and arterial pressure on plasma vasopressin in humans.
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心内压和动脉压升高对人体血浆加压素的影响。
DOI：
10.1152/ajpheart.1984.246.5.h647
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Cohn,JN
中科院分区：
文献类型：
--
作者：
Goldsmith,SR;CowleyJr,AW;Francis,GS;Cohn,JN
本文观察了18名健康青年轻度限水后心肺和窦弓压力感受器负荷对血浆精氨酸加压素（AVP）水平的影响。通过容量扩张使中心静脉压（CVP）从4.7 +/- 1.9 mmHg增加到7.3 +/- 2.2 mmHg，但不改变平均动脉压（MAP），从而急性负荷心血管受体。两个受体组都通过施加下体正压而受到急性负荷，这导致CVP出现相当的增加，此外，MAP从85 +/- 6.7升高至93 +/- 6.8 mmHg（P小于0.001）。有证据表明，当前臂血流和心率在容量扩张期间增加时，反射激活，而心率的增加在下体正压期间被阻断。两种干预均未显著改变对照组4.6 +/- 1.4 pg/ml的AVP水平。使用1小时的头向下倾斜进行了更长时间的心肺受体刺激的调查。同样，尽管CVP增加（5.1 +/- 1.3至9.0 +/- 1.4 mmHg，P <0.005），但AVP（5.7 +/- 2.4 pg/ml）并未降低。头低位时MAP无变化。在所有研究中，渗透压摩尔浓度均无变化。因此，在轻度限水条件下，人体AVP水平对心肺和窦主动脉压力感受器的中度等渗负荷没有反应。
The effects of loading cardiopulmonary and sinoaortic baroreceptors on plasma arginine vasopressin (AVP) levels were examined in 18 healthy young adults after a mild water restriction. Cardiopulmonary receptors were acutely loaded by volume expansion which increased central venous pressure (CVP) from 4.7 +/- 1.9 to 7.3 +/- 2.2 mmHg but did not change mean arterial blood pressure (MAP). Both receptor groups were acutely loaded by applications of lower body positive pressure, which induced a comparable increase in CVP and, in addition, raised MAP from 85 +/- 6.7 to 93 +/- 6.8 mmHg (P less than 0.001). There was evidence of reflex activation as forearm blood flow and heart rate increased during volume expansion while the increase in heart rate was blocked during lower body positive pressure. Neither intervention significantly altered the control AVP level of 4.6 +/- 1.4 pg/ml. An investigation of more prolonged stimulation of cardiopulmonary receptors was carried out using 1 h of head-down tilt. Again, despite increases in CVP (5.1 +/- 1.3 to 9.0 +/- 1.4 mmHg, P less than 0.005), AVP (5.7 +/- 2.4 pg/ml) did not decrease. MAP did not change during head-down tilt. There were no changes in osmolality throughout any of the studies. AVP levels in humans are therefore not responsive to moderate isosmotic loading of the cardiopulmonary and sinoaortic baroreceptors under conditions of mild water restriction.