The current status of toxicity protectants in cancer therapy.
The current status of toxicity protectants in cancer therapy.
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DOI：
10.5555/uri:pii:009377549290042y
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发表时间：
1992-12
影响因子：
4
通讯作者：
Lynn M. Schuchter;William Luginbuhl;N. Meropol
中科院分区：
文献类型：
--
作者：
Lynn M. Schuchter;William Luginbuhl;N. Meropol
Current therapies for the treatment of malignancies are associated with significant toxicity, as chemotherapy and radiation therapy do not discriminate between normal and malignant cells. One approach to ameliorating the toxicity associated with therapy is through the use of chemoprotective agents. This article reviews a variety of agents that have been evaluated as possible protectants, including WR-2721 and the colony-stimulating factors. It is hoped that the understanding of how to optimally use chemoprotective agents will lead to more tolerable treatments for patients, and possibly allow for dose-escalation, which may contribute to improvement in patient survival.
