Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis
Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis
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DOI：
10.1001/archneur.64.10.1416
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发表时间：
2007-10-01
影响因子：
--
通讯作者：
Gallo, Paolo
中科院分区：
文献类型：
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作者：
Calabrese, Massimiliano;De Stefano, Nicola;Gallo, Paolo
背景：体外研究证实多发性硬化症(MS)患者大脑皮质有明显的炎性病理改变。目的：确定活体多发性硬化症(MS)患者皮质内病变(ICL)的出现频率、出现时间和临床相关性。设计：双翻转恢复序列研究。地点：威尼托地区多发性硬化症中心。患者：2005年5月1日至12月31日，共纳入380例患者(临床隔离综合征116例，复发缓解MS 163例，继发性进展性MS 101例)和40名年龄和性别匹配的健康志愿者。主要观察指标：我们评估了ICL的频率和数量、脑实质分数、白质T2病变体积和临床功能障碍。结果：尽管在健康志愿者中从未观察到ICL，但58%的患者可以检测到ICL(36%的CIS患者，%的RRMS患者和73%的SPMS患者)。SPMS组ICL数明显高于CIS组和RRMS组(P
Background: A significant inflammatory pathologic disorder in the cortex of patients with multiple sclerosis ( MS) has been demonstrated by ex vivo studies.Objective: To determine the frequency, time of appearance, and clinical relevance of intracortical lesions (ICLs) in MS in vivo.Design: Double inversion recovery sequence study.Setting: Multiple Sclerosis Centre of the Veneto Region.Patients: We enrolled 380 patients (116 with clinically isolated syndrome [CIS], 163 with relapsing-remitting MS [RRMS], and 101 with secondary progressive MS [SPMS]) and 40 age- and sex-matched healthy volunteers between May 1, 2005, and December 31, 2006.Main Outcome Measures: We assessed the frequency and number of ICLs and brain parenchyma fraction, white matter T2 lesion volume, and clinical disability.Results: Although never observed in healthy volunteers, ICLs were detected in 58% of patients (36% of patients with CIS, 64% of patients with RRMS, and 73% of patients with SPMS). The number of ICLs was higher in patients with SPMS than in those with CIS or RRMS (P