Meta-analysis of the effectiveness of physical activity for the prevention of bone loss in postmenopausal women
Meta-analysis of the effectiveness of physical activity for the prevention of bone loss in postmenopausal women
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DOI：
10.1007/bf01623773
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发表时间：
1997-01-01
影响因子：
4
通讯作者：
Gauthier, P
中科院分区：
文献类型：
--
作者：
Berard, A;Bravo, G;Gauthier, P
进行了一项荟萃分析，以衡量身体活动对健康绝经后妇女骨量的影响。对1966年至1996年期间发表的所有研究（法语或英语）进行了综述，以纳入Medline检索、相关研究的参考书目、综述文章和书籍。研究必须是前瞻性干预试验，随机或非随机，评估任何持续时间，频率和强度的锻炼计划的有效性，并设有对照组。研究必须测量骨参数，并涉及50岁以上的健康绝经后妇女，这些妇女在进入研究时没有症状性骨质疏松症。根据Hedges和Olkin，计算每个合格研究中测量的每个骨参数和部位的效应量（ES）。DerSimonian和Laird模型用于估计合并研究时的总体效应量。所有分析均为骨参数和部位特异性分析。在从文献中提取的217篇论文中，187篇不符合合格标准，另外12篇被拒绝。拒绝的两个主要原因是分析中合并了两种性别，并且不存在无药物相互作用的运动组。纳入18项研究进行荟萃分析。考虑到频率，持续时间，遵守率和受试者的平均年龄，该计划被判断为中等强度，并侧重于步行，跑步，身体调理和有氧运动。在1991年以后发表的研究中，体力活动对腰椎L2-4水平的骨密度有显著影响（ES = 0.8745，p
A meta-analysis was done to measure the effect of physical activity on the bone mass of healthy postmenopausal women. All studies published between 1966 and 1996, in French or English, were reviewed for inclusion from Medline search, bibliographies of relevant studies, review articles and books. Studies had to be prospective intervention trials, randomized or not, evaluating the effectiveness of an exercise program of any duration, frequency and intensity, with a control group. Studies had to measure bone parameters and involve healthy postmenopausal women over 50 years of age who were free of symptomatic osteoporosis at the time of study entry. Effect sizes (ES) were calculated for each bone parameter and site measured in every eligible study according to Hedges and Olkin. DerSimonian and Laird's model was used to estimate overall effect sizes when combining studies. All analyses were bone parameter and site specific. Of 217 papers extracted from the literature, 187 did not meet eligibility criteria and 12 others were rejected. The two main reasons for rejection were that both genders were combined in the analyses and no exercise group without drug interaction was present. Eighteen studies were included for metaanalysis. Taking into account the frequency, duration, compliance rate and average age of the subjects, the programs were judged of moderate intensity and focused on walking, running, physical conditioning and aerobics. A significant effect of physical activity was detected on the bone mineral density at the L2-4 level of the lumbar column in studies published after 1991 (ES = 0.8745, p