OXIDATIVE STRESS IN TYPE 2 DIABETES WITH IRON DEFICIENCY IN ASIAN INDIANS
OXIDATIVE STRESS IN TYPE 2 DIABETES WITH IRON DEFICIENCY IN ASIAN INDIANS
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DOI：
10.2478/v10011-011-0049-8
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发表时间：
2012-04-01
影响因子：
2.5
通讯作者：
Marcus, Sara Rani
中科院分区：
文献类型：
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作者：
Ganesh, Swaminathan;Dharmalingam, Mala;Marcus, Sara Rani
铁代谢、糖尿病和氧化应激之间存在密切关系。糖尿病和氧化还原活性铁都是单独已知的增强氧化应激。然而，铁缺乏和氧化应激在糖尿病中的作用尚不清楚;因此，对2型糖尿病伴和不伴铁缺乏的氧化应激水平进行了比较。选择两组糖尿病患者各30例（一组缺铁，另一组铁水平正常），并与30名正常健康对照组进行比较。测量人体测量参数、空腹血糖、铁谱和氧化应激帕拉（丙二醛水平（脂质过氧化指数）和血清尿酸水平（抗氧化剂））。而糖尿病组血清铁蛋白水平显著升高，（急性期反应物和抗氧化剂）与正常对照相比（P=0.040），糖尿病缺铁组血清铁水平降低（P = 0.000）、铁蛋白（P = 0.000）和尿酸（P = 0.006）以及丙二醛水平升高（P = 0.000）。这项研究表明，缺铁糖尿病组的氧化应激增加以及抗氧化剂水平的降低可能进一步促进促氧化剂水平和炎症，从而导致这一高风险亚洲印度人群并发症的发展。
A close relationship exists between iron metabolism, diabetes and oxidative stress. Both diabetes and redox active iron are individually known to enhance oxidative stress. However, the role of iron deficiency and oxidative stress in diabetes is not clear; hence, the levels of oxidative stress in type 2 diabetes with and without iron deficiency have been compared. Two groups of 30 patients each with diabetes were selected (one group with iron deficiency and the other group with normal iron levels) and compared with 30 normal healthy controls. The anthropometric parameters, fasting blood sugar, iron profile and oxidative stress para meters (malondialdehyde levels (index of lipid peroxidation) and serum uric acid levels (antioxidant)) were measured. While the diabetes group had significantly increased serum levels of ferritin (an acute phase reactant and antioxidant) in comparison with normal controls (P=0.040), the diabetic group with iron deficiency had decreased serum levels of iron (P = 0.000), ferritin (P = 0.000) and uric acid (P = 0.006) and increased levels of malondialdehyde (P = 0.000) in comparison with diabetics without iron deficiency. This study shows an increase in oxidative stress in the diabetic group with iron deficiency together with reduction in antioxidant levels could further promote prooxidant levels and inflammation and in turn result in the development of complications in this high-risk Asian Indian population.