Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese.
Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese.
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DOI：
10.2217/pgs.15.184
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发表时间：
2016-08
期刊：
影响因子：
2.1
通讯作者：
S. Kasai;D. Nishizawa;Junko Hasegawa;N. Sato;F. Tanioka;H. Sugimura;K. Ikeda
中科院分区：
文献类型：
--
作者：
S. Kasai;D. Nishizawa;Junko Hasegawa;N. Sato;F. Tanioka;H. Sugimura;K. Ikeda
据报道，内源性阿片系统与烟草/尼古丁依赖有关。材料与方法研究了8个阿片受体相关基因的snp对日本人吸烟状况和吸烟相关性状的遗传影响。结果OPRL1基因rs2229205 SNP的基因型和等位基因变异与吸烟状况显著相关，但与吸烟相关性状的任何SNP的遗传变异均无显著差异。rs2229205 SNP与包含该SNP的连锁不平衡区中的其他SNP没有表现出高度的连锁不平衡。结论OPRL1基因rs2229205 SNP可能是导致日本人吸烟易感性个体差异的遗传因素。
AIM The endogenous opioid system has been reportedly implicated in tobacco/nicotine dependence. MATERIALS & METHODS We examined the genetic effects of eight SNPs in opioid receptor-related genes on smoking status and smoking-related traits in Japanese. RESULTS The genotypic and allelic variations of the rs2229205 SNP in the OPRL1 gene were significantly associated with smoking status, but no significant differences were found in the genetic variations of any of the SNPs with regard to smoking-related traits. The rs2229205 SNP did not show high linkage disequilibrium with the other SNPs in the linkage disequilibrium block that contained the SNP. CONCLUSION The rs2229205 SNP in the OPRL1 gene may be a genetic factor that contributes to individual differences in the vulnerability to smoking in Japanese individuals.