Size at birth, infant growth, and blood pressure at three years of age
Size at birth, infant growth, and blood pressure at three years of age
复制标题
DOI：
10.1016/j.jpeds.2007.05.010
复制
发表时间：
2007-12-01
影响因子：
5.1
通讯作者：
Gillman, Matthew W.
中科院分区：
文献类型：
--
作者：
Belfort, Mandy B.;Rifas-Shiman, Sheryl L.;Gillman, Matthew W.
目的我们的目的是确定婴儿从出生到6个月的身高体重增长与3岁时收缩压（SBP）的相关程度，并确定这种相关性是否随出生尺寸而变化。研究设计在来自前瞻性队列Project Viva的530名儿童中，我们用研究标准仪器测量了出生时的身长和6个月时的体重和身长，用Dinamap自动记录仪测量了3岁时的SBP。结果出生时和6个月时的平均（SD）WFL-z分别为0.47（0.75）和0.70（0.96）。3年时的平均（SD）SBP为91.7（9.4）mmHg。在调整混杂变量和出生WFL-z后，6个月WFL-z中每增加一个z评分，儿童SBP增加1.0 mmHg（95% CI 0.2，1.8）。出生时WFL-z最低四分位数和6个月WFL-z最高四分位数儿童的SBP为5.5 mm Hg（95%CI 2.6，8.4）高于最高出生和最低6个月WFL-z四分位数的儿童。特别是出生时就很瘦的孩子。
Objectives Our aim was to determine the extent to which infant growth-in weight-for-length-from birth to 6 months is associated with systolic blood pressure (SBP) at 3 years and to determine whether this association varies with birth size.Study design In 530 children from the prospective cohort Project Viva, we measured birth length and 6-month weight and length with research standard instruments and SBP at age 3 years with a Dinamap automated recorder. We derived weight-for-length z-scores (WFL-z) and analyzed data with mixed effects regression models.Results The mean (SD) WFL-z was 0.47 (0.75) at birth and 0.70 (0.96) at 6 months. Mean (SD) SBP at 3 years was 91.7 (9.4) nun Hg. After adjusting for confounding variables and birth WFL-z, child SBP was 1.0 mm Hg (95% CI 0.2, 1.8) higher for each z-score increment in 6-month WFL-z. The SBP of children in the lowest birth WFL-z quartile and the highest 6-month WFL-z quartile was 5.5 mm Hg (95% Cl 2.6, 8.4) higher than that of children in the highest birth and lowest 6-month WFL-z quartiles.Conclusions More rapid increase in weight-for-length, a measure of adiposity, in the first 6 months of life is associated with higher early childhood SBP, particularly in children who are thin at birth.